An Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neem seed oil demonstrated lowtoxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine.

Phytochemical analyses and pharmacological screening of Neem oil / S. Cesa, F. Sisto, G. Zengin, D. Scaccabarozzi, A.K. Kokolakis, M.M. Scaltrito, R. Grande, M. Locatelli, F. Cacciagrano, L. Angiolella, C. Campestre, A. Granese, P. Chimenti, N. Basilico. - In: SOUTH AFRICAN JOURNAL OF BOTANY. - ISSN 0254-6299. - 120(2019 Jan), pp. 331-337.

Phytochemical analyses and pharmacological screening of Neem oil

F. Sisto
Secondo
;
D. Scaccabarozzi;M.M. Scaltrito;N. Basilico
Ultimo
2019

Abstract

An Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neem seed oil demonstrated lowtoxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine.
Color analysis; HPLC-PDA; H. pylori; Neem oil; Malaria; Leishmania; Enzyme inhibition
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/04 - Patologia Generale
gen-2019
15-nov-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/603672
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