Background: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). Methods: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. Results: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months). The hazard ratio (HR) comparing the third and the first quartiles of the distribution of number of patients per center showed an advantage in PFS (HR 0.59, range 0.53-0.65, P < .0001) and in OS (HR 0.70, 0.60-0.81, P < .0001) for centers with a higher number of patients recruited. A similar benefit was observed in PFS (HR 0.63, 0.60-0.66) and OS (HR 0.74, 0.69-0.79) considering the mean number of patients per year. Conclusions: The PFS and OS were longer for patients treated in high-casevolume centers.
Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials / P. Bossi, R. Miceli, M. Benasso, R. Corvò, A. Bacigalupo, G. Sanguineti, C. Fallai, M.C. Merlano, G. Infante, C. Dani, V. Di Giannantonio, L. Licitra. - In: HEAD & NECK. - ISSN 1043-3074. - 40:12(2018 Dec), pp. 2648-2656.
|Titolo:||Impact of treatment expertise on the outcome of patients with head and neck cancer treated within 6 randomized trials|
|Parole Chiave:||HNCC; referral centers; survival; treatment expertise|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||dic-2018|
|Data ahead of print / Data di stampa:||17-nov-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/hed.25389|
|Appare nelle tipologie:||01 - Articolo su periodico|