Purpose: To evaluate the incidence and predictors for late toxicity and tumor outcome after hypofractionated radiotherapy using three different image-guided radiotherapy (IGRT) systems (hypo-IGRT) compared with conventional fractionation without image guidance (non-IGRT). Methods and materials: We compared the late rectal and urinary toxicity and outcome in 179 prostate cancer patients treated with hypo-IGRT (70.2 Gy/26 fractions) and 174 non-IGRT patients (80 Gy/40 fractions). Multivariate analysis was performed to define predictors for late toxicity. 5- and 8-year recurrence-free survival (RFS) and overall survival (OS) were analyzed. Results: Mean follow-up was 81 months for hypo-IGRT and 90 months for non-IGRT group. Mainly mild late toxicity was observed: Hypo-IGRT group experienced 65 rectal (30.9% G1/G2; 6.3% G3/G4) and 105 urinary events (56% G1/G2; 4% G3/G4). 5- and 8-year RFS rates were 87.5% and 86.8% (hypo-IGRT) versus 80.4% and 66.8% (non-IGRT). 5- and 8-year OS rates were 91.3% and 82.7% in hypo-IGRT and 92.2% and 84% in non-IGRT group. Multivariate analysis showed that hypo-IGRT is a predictor for late genitourinary toxicity, whereas hypo-IGRT, acute urinary toxicity and androgen deprivation therapy are predictors for late rectal toxicity. Advanced T stage and higher Gleason score (GS) were correlated with worse RFS. Conclusions: A small increase in mild late toxicity, but not statistically significant increase in severe late toxicity in the hypo-IGRT group when compared with conventional non-IGRT group was observed. Our study confirmed that IGRT allows for safe moderate hypofractionation, offering a shorter overall treatment time, a good impact in terms of RFS and providing potentially more economic health care.
Late toxicity of image-guided hypofractionated radiotherapy for prostate : non-randomized comparison with conventional fractionation / B.A. Jereczek-Fossa, A. Surgo, P. Maisonneuve, A. Maucieri, M.A. Gerardi, D. Zerini, G. Marvaso, D. Ciardo, S. Volpe, D.P. Rojas, G. Riva, O. Alessandro, S. Dicuonzo, G. Fanetti, P. Romanelli, A. Starzyńska, F. Cattani, R. Cambria, C. Fodor, C. Garibaldi, C. Romanò, O. De Cobelli, R. Orecchia. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 124:1(2019 Jan 24), pp. 65-78.
|Titolo:||Late toxicity of image-guided hypofractionated radiotherapy for prostate : non-randomized comparison with conventional fractionation|
JERECZEK, BARBARA ALICJA (Primo)
SURGO, ALESSIA (Secondo) (Corresponding)
DE COBELLI, OTTAVIO (Penultimo)
ORECCHIA, ROBERTO (Ultimo)
|Parole Chiave:||Conventional fractionation; Hypofractionation; Image-guided radiotherapy; Late toxicity; Prostate cancer; Radiology, Nuclear Medicine and Imaging|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
Settore MED/36 - Diagnostica per Immagini e Radioterapia
|Data di pubblicazione:||24-gen-2019|
|Data ahead of print / Data di stampa:||15-set-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11547-018-0937-9|
|Appare nelle tipologie:||01 - Articolo su periodico|