Background: PM2.5 has been associated with acute cardiovascular outcomes, but our understanding of the mechanisms is incomplete. Methods: We examined the association of PM2.5 and black carbon (BC), a marker of traffic particles, with serum concentrations of Intercellular Adhesion Molecule (ICAM) and Vascular Cellular Adhesion Molecule (VCAM) in a repeated measures study of 710 participants of the Normative Aging Study who were seen at least once since 2000 (1178 total observations). ICAM and VCAM were measured by ELISA assay. We used mixed regression models to examine the association of ambient particle concentrations with these outcomes, controlling for time (natural spline with 4 df/yr), age, BMI, smoking (never/former/current plus pack-years), diabetes, race, and statin use. Results: Both PM2.5 (3.4% increase per 10g/m3, 95% CI 1.2,5.7) and BC (5.8% increase per 1g/m3 95% CI 1.9, 9.6) during the 24 hours prior to blood draw were significantly associated with increased VCAM. Neither pollutant was associated with ICAM. For PM2.5, but not BC, the pollution-VCAM association was modified by HFE variants (p=.048), statin use (p=.042), and obesity (p=.043), and to a lesser extent by GSTM1 (p=.057), where increased effects of PM2.5 were seen in subjects who were obese, homozygous wildtype for HFE, GSTM1 null, or taking statins. Conclusions: Ambient particles are associated with endothelial dysfunction, with associations modified by genes related to oxidative defense, and metal processing. The latter suggests that metals on the particles may be important to this response.
|Titolo:||PM2.5, genes, and serum markers of endothelial function : the VA normative aging study|
BACCARELLI, ANDREA (Secondo)
|Data di pubblicazione:||mag-2008|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Citazione:||PM2.5, genes, and serum markers of endothelial function : the VA normative aging study / J. Madrigano, A. Baccarelli, H. Suh, D. Sparrow, P. Vokonas, J.D. Schwartz. ((Intervento presentato al convegno American Thoracic Society 2008 tenutosi a Toronto nel 2008.|
|Appare nelle tipologie:||14 - Intervento a convegno non pubblicato|