The electrical properties of biological tissues differ depending on their structural characteristics. In literature, a lot of study have been carried out with the intent of taking advantage of bioimpedance analysis. Unfortunately, many apparatuses used during these campaigns were not always designed for measurements on living tissues. As a consequence, data could be affected by electrode polarization. In 2016, we presented a new impedance meter, developed for measurements on living tissues. Initially, it was tested only on ex-vivo rabbit’s tissues with promising results. As a continuation, this device has been tested on in-vivo samples by placing a needle-probe into 3 tissues (liver, spleen, ovary) of 2 female dogs. Furthermore, was evaluated also the bioimpedance signal of the ovary explanted, comparing it with the in-vivo data. Bioimpedance was analyzed in terms of modulus and phase along a broad spectrum of frequencies (10Hz – 10kHz). Data obtained confirm the possibility of discriminating among the 3 tested tissues, at high frequencies for modulus and at low for phase. Confirmation that values on in-vivo and ex-vivo tissues are comparable if detected within few minutes after the explant, is also reported. We conclude that this clinical evaluation confirmed, also in-vivo, the good performance of the device previously tested on ex-vivo tissues, and provide more information about the tissue properties and characteristics.

In-Vivo Measurements of Tissue Impeditivity by Electrical Impedance Spectroscopy / D. Meroni, D. Bovio, M. Gualtieri, A. Aliverti (PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)[s.l] : Institute of Electrical and Electronics Engineers (IEEE), 2018 Oct 29. - ISBN 9781538636466. - pp. 5306-5309 (( Intervento presentato al 40. convegno EMBC Annual International Conference of the IEEE Engineering in Medicine and Biology Society : July, 18th - 21st tenutosi a Honolulu (HI, USA) nel 2018.

In-Vivo Measurements of Tissue Impeditivity by Electrical Impedance Spectroscopy

Massimo Gualtieri;
2018-10-29

Abstract

The electrical properties of biological tissues differ depending on their structural characteristics. In literature, a lot of study have been carried out with the intent of taking advantage of bioimpedance analysis. Unfortunately, many apparatuses used during these campaigns were not always designed for measurements on living tissues. As a consequence, data could be affected by electrode polarization. In 2016, we presented a new impedance meter, developed for measurements on living tissues. Initially, it was tested only on ex-vivo rabbit’s tissues with promising results. As a continuation, this device has been tested on in-vivo samples by placing a needle-probe into 3 tissues (liver, spleen, ovary) of 2 female dogs. Furthermore, was evaluated also the bioimpedance signal of the ovary explanted, comparing it with the in-vivo data. Bioimpedance was analyzed in terms of modulus and phase along a broad spectrum of frequencies (10Hz – 10kHz). Data obtained confirm the possibility of discriminating among the 3 tested tissues, at high frequencies for modulus and at low for phase. Confirmation that values on in-vivo and ex-vivo tissues are comparable if detected within few minutes after the explant, is also reported. We conclude that this clinical evaluation confirmed, also in-vivo, the good performance of the device previously tested on ex-vivo tissues, and provide more information about the tissue properties and characteristics.
electrical impedance spectroscopy; bioimpedance; tissue impeditivity
Settore VET/09 - Clinica Chirurgica Veterinaria
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
Settore MED/06 - Oncologia Medica
Settore MED/18 - Chirurgia Generale
Institute of Electrical and Electronics Engineers (IEEE)
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/602080
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