The key role of T cells in the pathogenesis of cutaneous psoriasis has been well described in the last decade and the knowledge of the relative role of the different subsets of T cells in psoriasis pathogenesis has considerably evolved. Now, it is clear that IL-17A-producing T cells, including Th17/Tc17, have a central role in the pathogenesis of cutaneous psoriasis and therapies blocking the IL-17A pathway show high clinical efficacy. By contrast, the contribution of IFNγ-producing T cells has progressively become less clear because of the lack of efficacy of anti-IFNγ antibodies in clinical studies. In parallel, the role of CD8+T cells specific for self-antigens has been revived and increasing evidence now indicates that in psoriatic skin the majority CD8+T cells are present in the form of epidermal tissue-resident memory T cells. In the last years it also emerged the possibility of a contribution of T cell recirculation in the pathogenesis of psoriasis and its systemic manifestations. The aim of this review is to define a hierarchy for the different subsets of T cells in the T cell-mediated inflammatory cascade in psoriatic skin. This analysis will possibly help to distinguish the subsets that initiate the disease, those involved in the establishment of the self-sustaining amplification loop that leads to the cutaneous clinical manifestations and finally the subsets that act as downstream players in established lesions. Specific T cell subpopulations finally will be considered for their possible role in propagating inflammation at distant sites and for representing a link with systemic inflammation and cardiovascular comorbidities.
T cell hierarchy in the pathogenesis of psoriasis and associated cardiovascular comorbidities / F. Casciano, P.D. Pigatto, P. Secchiero, R. Gambari, E. Reali. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 9(2018), pp. 1390.1-1390.8.
|Titolo:||T cell hierarchy in the pathogenesis of psoriasis and associated cardiovascular comorbidities|
PIGATTO, PAOLO DANIELE MARIA [Conceptualization]
|Parole Chiave:||Comorbidities; Inflammation; Psoriasis; Psoriatic arthritis; Skin; TCR repertoire; Immunology and Allergy; Immunology|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fimmu.2018.01390|
|Appare nelle tipologie:||01 - Articolo su periodico|