There is controversy surrounding the existence of palmoplantar pustulosis (PPP) and psoriasis as separate clinical entities, or as variants of the same clinical entity. PPP is usually defined as a chronic skin disease characterized by crops of sterile pustules with erythema and sometimes scaling on the palms and soles. PPP has in some studies been associated with autoimmune conditions such as thyroid diseases and celiac disease. Positive patch test reactions to several metals have been documented in patients with PPP, and notably, removal of dental alloys with these metals has been reported in some cases to result in the resolution of skin manifestations, suggesting a causative relationship. PPP is associated with moderate-to-severe discomfort and disability and is difficult to treat, often requiring the use of immunosuppressive agents.

Metal allergy and palmoplantar pustulosis / P.D. Pigatto, G. Guzzi - In: Metal Allergy : From Dermatitis to Implant and Device Failure / [a cura di] J.K Chen, J.P. Thyssen. - Prima edizione. - [s.l] : Springer International Publishing, 2018. - ISBN 9783319585031. - pp. 545-549

Metal allergy and palmoplantar pustulosis

P.D. Pigatto
;
2018

Abstract

There is controversy surrounding the existence of palmoplantar pustulosis (PPP) and psoriasis as separate clinical entities, or as variants of the same clinical entity. PPP is usually defined as a chronic skin disease characterized by crops of sterile pustules with erythema and sometimes scaling on the palms and soles. PPP has in some studies been associated with autoimmune conditions such as thyroid diseases and celiac disease. Positive patch test reactions to several metals have been documented in patients with PPP, and notably, removal of dental alloys with these metals has been reported in some cases to result in the resolution of skin manifestations, suggesting a causative relationship. PPP is associated with moderate-to-severe discomfort and disability and is difficult to treat, often requiring the use of immunosuppressive agents.
Medicine (all); Immunology and Microbiology (all)
Settore MED/35 - Malattie Cutanee e Veneree
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/601257
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