In the last decade numerous publications highlighted the connection between metabolism and epigenetics in different physiological and pathological conditions. The availability of metabolites for cells represents indeed a crucial factor, which is able to condition cell fate and development, differentiation and proliferation partially trough epigenetic control. This tight link provides novel therapeutic possibilities to treat many pathological conditions induced by epigenetic alterations, by manipulating metabolic pathways producing metabolites that work also as epigenetic modifiers. This review will explore specifically the relevance of epigenetics and metabolism in the onset of metabolic disorders and cancer, highlighting potential epigenetic-based pharmacological approaches for the treatment of these disorders trough a rewiring of cellular metabolism. We will also report recent studies on stem cells, demonstrating how epigenetic setting is influenced by metabolism and how these processes affect cell pluripotency and differentiation capacity. These findings suggest a big pharmacological potential, as the modulation of epigenetics and metabolism in stem cells may represent a new tool for regenerative medicine, offering a plethora of novel possibilities for the treatment of severe pathological conditions.

Epigenome modifiers and metabolic rewiring: New frontiers in therapeutics / A. Ferrari, R. Longo, R. Silva, N. Mitro, D. Caruso, E. De Fabiani, M. Crestani. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - 193(2019 Jan), pp. 178-193. [10.1016/j.pharmthera.2018.08.008]

Epigenome modifiers and metabolic rewiring: New frontiers in therapeutics

A. Ferrari
Primo
;
R. Longo
Secondo
;
R. Silva;N. Mitro;D. Caruso;E. De Fabiani
Penultimo
;
M. Crestani
Ultimo
2019-01

Abstract

In the last decade numerous publications highlighted the connection between metabolism and epigenetics in different physiological and pathological conditions. The availability of metabolites for cells represents indeed a crucial factor, which is able to condition cell fate and development, differentiation and proliferation partially trough epigenetic control. This tight link provides novel therapeutic possibilities to treat many pathological conditions induced by epigenetic alterations, by manipulating metabolic pathways producing metabolites that work also as epigenetic modifiers. This review will explore specifically the relevance of epigenetics and metabolism in the onset of metabolic disorders and cancer, highlighting potential epigenetic-based pharmacological approaches for the treatment of these disorders trough a rewiring of cellular metabolism. We will also report recent studies on stem cells, demonstrating how epigenetic setting is influenced by metabolism and how these processes affect cell pluripotency and differentiation capacity. These findings suggest a big pharmacological potential, as the modulation of epigenetics and metabolism in stem cells may represent a new tool for regenerative medicine, offering a plethora of novel possibilities for the treatment of severe pathological conditions.
Cancer; Epigenetics; Metabolic disease; Metabolic regulation; Stem cells
Settore BIO/10 - Biochimica
Control of metabolic and inflammatory pathways by nuclear receptor
Health and Understanding of Metabolism, Aging and Nutrition
Histone deacetylase 3 in adipose tissue: a link between immuno-metabolic dysfunctions and obesity and type 2 diabetes
Dipartimenti di Eccellenza 2018-2022 - Dipartimento di SCIENZE FARMACOLOGICHE E BIOMOLECOLARI
ago-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/600098
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