Objectives: In comparison with Europeans Russian population shows enormously high levels of cardiovascular mortality and morbidity. A recent European study (IMPROVE) has revealed the existence of a geographical gradient in subclinical atherosclerosis which parallels with the North-to South geographical gradient in cardiovascular mortality described in the WHO Europe database. This study was kept to characterize the variability of common carotid intima-media thickness (cIMT) in selected high-risk population sample recruited in Moscow (n=407) and Milan (n=435), and to investigate the hypothesis of West-to-East cIMT gradient, as well as to elucidate the role of cardiovascular risk factor in between-population cIMT variability. Methods: Asymptomatic men and women (55-79 yrs) with at least three cardiovascular risk factors were eligible. Different from the IMPROVE Study, ultrasonic scans were taken from the distal centimeter of common carotid arteries only. Quantification of cIMT was performed in Monzino Cardiology Center (Milan, Italy) by a qualified reader using Mat'h software. Results: The comparative analysis has revealed that the mean (95% CI) cIMT value was significantly higher in Moscow - 0.82 (0.81-0.85) mm than in Milan - 0.73 (0.72-0.74) mm (p<0.001). Moscow study participants have higher prevalence of arterial hypertension, blood pressure, total and HDL cholesterol and triglycerides, and take less medication. However, these differences explains only 16% between-population difference in cIMT variability. Decision tree analysis has revealed that the site of residence has a decisive impact on the observed difference in cIMT variability. The association between cIMT and the standardized mortality ratio for IHD reported in the WHO European database is non-linear (R-square 0.86, p<0.001 for logarithmic correlation). Conclusion: Cardiovascular mortality in Russia is only partially explained by a higher atherosclerotic risk profile; genetic and environmental factors should be strongly involved in between-population difference in cIMT variability, which can help explaining the striking difference in cardiovascular mortality between European and Russian populations.

The comparative study of common carotid intima-media thickness in Russian and Italian high-risk individuals / I. Sobenin, V. Orekhova, Y. Bobryshev, A. Orekhov, V. Myasoedova, A. Ravani, E. Tremoli, D. Baldassarre. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 235:2(2014 Aug), pp. E233-E233. ((Intervento presentato al 82. convegno Congress of the European-Atherosclerosis-Society (EAS) tenutosi a Madrid nel 2014 [10.1016/j.atherosclerosis.2014.05.694].

The comparative study of common carotid intima-media thickness in Russian and Italian high-risk individuals

E. Tremoli;D. Baldassarre
2014-08

Abstract

Objectives: In comparison with Europeans Russian population shows enormously high levels of cardiovascular mortality and morbidity. A recent European study (IMPROVE) has revealed the existence of a geographical gradient in subclinical atherosclerosis which parallels with the North-to South geographical gradient in cardiovascular mortality described in the WHO Europe database. This study was kept to characterize the variability of common carotid intima-media thickness (cIMT) in selected high-risk population sample recruited in Moscow (n=407) and Milan (n=435), and to investigate the hypothesis of West-to-East cIMT gradient, as well as to elucidate the role of cardiovascular risk factor in between-population cIMT variability. Methods: Asymptomatic men and women (55-79 yrs) with at least three cardiovascular risk factors were eligible. Different from the IMPROVE Study, ultrasonic scans were taken from the distal centimeter of common carotid arteries only. Quantification of cIMT was performed in Monzino Cardiology Center (Milan, Italy) by a qualified reader using Mat'h software. Results: The comparative analysis has revealed that the mean (95% CI) cIMT value was significantly higher in Moscow - 0.82 (0.81-0.85) mm than in Milan - 0.73 (0.72-0.74) mm (p<0.001). Moscow study participants have higher prevalence of arterial hypertension, blood pressure, total and HDL cholesterol and triglycerides, and take less medication. However, these differences explains only 16% between-population difference in cIMT variability. Decision tree analysis has revealed that the site of residence has a decisive impact on the observed difference in cIMT variability. The association between cIMT and the standardized mortality ratio for IHD reported in the WHO European database is non-linear (R-square 0.86, p<0.001 for logarithmic correlation). Conclusion: Cardiovascular mortality in Russia is only partially explained by a higher atherosclerotic risk profile; genetic and environmental factors should be strongly involved in between-population difference in cIMT variability, which can help explaining the striking difference in cardiovascular mortality between European and Russian populations.
Settore BIO/14 - Farmacologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
Sobenin PIIS0021915014009307.pdf

accesso riservato

Descrizione: Abstract pubblicato su rivista internazionale con IF
Tipologia: Publisher's version/PDF
Dimensione 198.5 kB
Formato Adobe PDF
198.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/597080
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 1
social impact