Until a few years ago, the majority of cell functions were envisioned as the result of protein and DNA activity. The cell membranes were considered as a mere structure of support and/or separation. In the last years, the function of cell membranes has, however, received more attention and their components of lipid nature have also been depicted as important cell mediators and the membrane organization was described as an important determinant for membrane-anchored proteins activity. In particular, due to their high diversity, glycosphingolipids offer a wide possibility of regulation. Specifically, the role of glycosphingolipids, in the fine-tuning of neuron activity, has recently received deep attention. For their pivotal role in vertebrate and mammals neural development, neural stem cells regulation is of main interest especially concerning their further functions in neurological pathology progression and treatment. Glycosphingolipids expression present a developmental regulation. In this view, glycosphingolipids can hold an important role in neural stem cells features due to their heterogeneity and their consequent capacity for eclectic interaction with other cell components.

The Crosstalk Between Glycosphingolipids And Neural Stem Cells / D. Bottai, R. Adami, R. Ghidoni. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 148:6(2019 Mar), pp. 698-711. [10.1111/jnc.14600]

The Crosstalk Between Glycosphingolipids And Neural Stem Cells

D. Bottai
Primo
;
R. Adami
Secondo
;
R. Ghidoni
Ultimo
2019

Abstract

Until a few years ago, the majority of cell functions were envisioned as the result of protein and DNA activity. The cell membranes were considered as a mere structure of support and/or separation. In the last years, the function of cell membranes has, however, received more attention and their components of lipid nature have also been depicted as important cell mediators and the membrane organization was described as an important determinant for membrane-anchored proteins activity. In particular, due to their high diversity, glycosphingolipids offer a wide possibility of regulation. Specifically, the role of glycosphingolipids, in the fine-tuning of neuron activity, has recently received deep attention. For their pivotal role in vertebrate and mammals neural development, neural stem cells regulation is of main interest especially concerning their further functions in neurological pathology progression and treatment. Glycosphingolipids expression present a developmental regulation. In this view, glycosphingolipids can hold an important role in neural stem cells features due to their heterogeneity and their consequent capacity for eclectic interaction with other cell components.
Central nervous system; development; glycosphingolipids; neural stem cells; neurogenesis
Settore BIO/13 - Biologia Applicata
Settore BIO/14 - Farmacologia
Settore BIO/10 - Biochimica
Settore BIO/09 - Fisiologia
Settore BIO/11 - Biologia Molecolare
30-set-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/596448
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