Although vitamin D was initially considered a nutrient, it has been recognized that the molecules derived from vitamin D metabolism are best considered as a complex endocrine system. In this review article we summarize the basic concepts regarding vitamin D metabolism, transport, and genomic activity through the vitamin D receptor, facilitating activation or suppression of target genes. We also examine non-genomic actions, biological responses to vitamin D in classic target organs (intestine, bone, kidneys, and parathyroid glands), and in organs and tissues not related to mineral homeostasis.
|Titolo:||Vitamin D: physiology and pathophysiology|
GALLIENI, MAURIZIO ALBERTO (Primo)
COZZOLINO, MARIO GENNARO (Secondo)
BRANCACCIO, DIEGO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||2009|
|Appare nelle tipologie:||01 - Articolo su periodico|