The IFNL4 knock-out allele (rs368234815-TT) is associated with spontaneous and IFNA-dependent cure of HCV. The role of this polymorphism in susceptibility to HIV-1 infection is controversial. This study is aimed to assess the association of this knock-out IFNL4 gene variant and sexually transmitted HIV-1 infection. 228 HIV-1 positive and 136 HIV-exposed seronegatives were investigated for their association with IFNL4 rs368234815 genotypes. The IFNL4 G functional allele is associated to increased susceptibility to HIV-1 infection through sexual route OR: 2.1 95% CI (1.2-3.6), P=0.004. A meta-analysis including an IDU population suggests a codominant mode of inheritance of this risk factor OR: 2.0 95% CI (1.3-3.2), P=0.001.
Knock-out IFNL4 gene variant is associated with protection from sexually transmitted HIV-1 infection / C. Jaimes-Bernal, N. Rallón, J. Benito, M.O. Mohamed-Balghata, M.A. Gómez-Vidal, F.J. Márquez, B. Sánchez-Arcas, M. Trujillo, J.L. Royo, I. Saulle, M. Biasin, . Rivero-Juárez, A. Caruz .. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - (2018). [Epub ahead of print] [10.1093/infdis/jiy584]
Knock-out IFNL4 gene variant is associated with protection from sexually transmitted HIV-1 infection
I. Saulle;M. Biasin;
2018
Abstract
The IFNL4 knock-out allele (rs368234815-TT) is associated with spontaneous and IFNA-dependent cure of HCV. The role of this polymorphism in susceptibility to HIV-1 infection is controversial. This study is aimed to assess the association of this knock-out IFNL4 gene variant and sexually transmitted HIV-1 infection. 228 HIV-1 positive and 136 HIV-exposed seronegatives were investigated for their association with IFNL4 rs368234815 genotypes. The IFNL4 G functional allele is associated to increased susceptibility to HIV-1 infection through sexual route OR: 2.1 95% CI (1.2-3.6), P=0.004. A meta-analysis including an IDU population suggests a codominant mode of inheritance of this risk factor OR: 2.0 95% CI (1.3-3.2), P=0.001.File | Dimensione | Formato | |
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