The present study was undertaken to evaluate the possible alterations of the triangle of Guillain and Mollaret (G-Mt), a neuronal brainstem/cerebellum network (from the dentate nucleus to red nucleus and inferior olivary nucleus) already known for its involvement in the pathogenesis of the palatal myoclonus, in sudden unexplained perinatal and infant death. In 44 cases of perinatal and infant death victims, aged from 26 gestational weeks to 10 months of life, we investigated, besides the histological morphology of the three nuclei, the c-fos and apoptotic expression, as well as the possible effects elicited by maternal cigarette smoking. A significant increase of lesions (hypoplasia and/or increased c-fos and apoptotic neuronal immunopositivity) of the three nuclei was found in unexplained death victims, compared with age-matched controls. These alterations were related to maternal cigarette smoking habit. We postulated that the G-Mt is an important network involved in the pathogenesis of a wide spectrum of pathological manifestations and that maternal smoking during pregnancy can exert an adverse influence on this complex, even leading to sudden death in vulnerable periods of perinatal or infant development

NEUROPATHOLOGY OF THE GUILLAIN-MOLLARET TRIANGLE (DENTATO-RUBRO-OLIVARY NETWORK) IN SUDDEN UNEXPLAINED PERINATAL DEATH AND SIDS / A.M. Lavezzi, M. Corna, L. Matturri, F. Santoro. - In: THE OPEN NEUROLOGY JOURNAL. - ISSN 1874-205X. - 3:(2009), pp. 66-71.

NEUROPATHOLOGY OF THE GUILLAIN-MOLLARET TRIANGLE (DENTATO-RUBRO-OLIVARY NETWORK) IN SUDDEN UNEXPLAINED PERINATAL DEATH AND SIDS

A.M. Lavezzi
Primo
;
M. Corna
Secondo
;
L. Matturri
Penultimo
;
F. Santoro
Ultimo
2009

Abstract

The present study was undertaken to evaluate the possible alterations of the triangle of Guillain and Mollaret (G-Mt), a neuronal brainstem/cerebellum network (from the dentate nucleus to red nucleus and inferior olivary nucleus) already known for its involvement in the pathogenesis of the palatal myoclonus, in sudden unexplained perinatal and infant death. In 44 cases of perinatal and infant death victims, aged from 26 gestational weeks to 10 months of life, we investigated, besides the histological morphology of the three nuclei, the c-fos and apoptotic expression, as well as the possible effects elicited by maternal cigarette smoking. A significant increase of lesions (hypoplasia and/or increased c-fos and apoptotic neuronal immunopositivity) of the three nuclei was found in unexplained death victims, compared with age-matched controls. These alterations were related to maternal cigarette smoking habit. We postulated that the G-Mt is an important network involved in the pathogenesis of a wide spectrum of pathological manifestations and that maternal smoking during pregnancy can exert an adverse influence on this complex, even leading to sudden death in vulnerable periods of perinatal or infant development
dentate nucleus ; inferior olivary nucleus ; red nucleus ; palatal myoclonus ; maternal cigarette smoking ; SIDS ; unexplained perinatal death
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/08 - Anatomia Patologica
2009
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/59235
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