NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.
The yin-yang of the interaction between myelomonocytic cells and NK cells / M. Molgora, D. Supino, D. Mavilio, A. Santoni, L. Moretta, A. Mantovani, C. Garlanda. - In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - ISSN 0300-9475. - 88:3(2018 Sep).
The yin-yang of the interaction between myelomonocytic cells and NK cells
D. Mavilio;
2018
Abstract
NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.File | Dimensione | Formato | |
---|---|---|---|
ZZZO:Molgora M. et al 2018-Scandinavian Journal of Immunology.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
849.12 kB
Formato
Adobe PDF
|
849.12 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.