We have recently introduced "inherently chiral" enantiopure electrode surfaces of outstanding chirality manifestations, including circularly polarized luminescence, reversibly potential-driven circular dichroism, and large potential differences for the enantiomers of chiral probes in voltammetry experiments performed on such surfaces. [1-3] The outstandingly powerful “inherent chirality” concept implies a molecular structure where the stereogenic element does not consist in an isolated stereocentre or an external chirality source, but originates from a tailored torsion in the whole main backbone endowing the molecule with its key functional property (here electroactivity). A key issue is now to investigate the enantioselection mechanism and to optimize the experimental protocols for the deposition of our inherently chiral surfaces. For both aims it is important to study the thickness and regularity of the chiral oligomer films as a function of the experimental conditions. We started a systematic profilometry study correlated to electrochemical impedance spectroscopy measurements of the oligomer films obtained by carefully controlled electrodeposition, varying one by one different experimental parameters. The study is also important to properly compare enantioselection by films prepared from different inherently chiral monomers, including e.g. bisindole and tetrathiahelicene ones.  S. Arnaboldi, S. Grecchi, M. Magni, P. Mussini, Electroactive chiral oligo- and polymer layers for electrochemical enantiorecognition, Current Opinion in Electrochemistry, 7 (2018) 188-199.  S. Arnaboldi, M. Magni, P. R. Mussini, Enantioselective selectors for chiral electrochemistry and electroanalysis: Stereogenic elements and enantioselection performance, Current Opinion in Electrochemistry, 8 (2018) 60-72.  S. Arnaboldi, T. Benincori, R. Cirilli, S. Grecchi, L. Santagostini, F. Sannicolò, P.R. Mussini, “Inherently chiral” thiophene-based electrodes at work: a screening of enantioselection ability toward a series of pharmaceutically relevant phenolic or catecholic amino acids, amino esters, and amine, Analytical and Bioanalytical Chemistry, 408 (2016) 7243-7254.
|Titolo:||Optimizing the electrodeposition protocol of enantioselective inherently chiral electrode surfaces: a multi-technique investigation|
|Data di pubblicazione:||set-2018|
|Settore Scientifico Disciplinare:||Settore CHIM/01 - Chimica Analitica|
|Citazione:||Optimizing the electrodeposition protocol of enantioselective inherently chiral electrode surfaces: a multi-technique investigation / S. Arnaboldi, M. Magni, P. Mussini, T. Benincori, S. Cauteruccio. ((Intervento presentato al 27. convegno Congresso della Divisione di Chimica Analitica tenutosi a Bologna nel 2018.|
|Appare nelle tipologie:||14 - Intervento a convegno non pubblicato|