A 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Microscopically, renal medullary cysts and medullary atrophy resembled the changes associated with polycystic kidney disease (PKD). The cysts of the paraduodenal mass were lined by ciliated epithelial cells resembling embryonal cells and were intensely positive for glucagon and insulin by IHC. There was no cytokeratin expression in either lesion. WT-1 expression in the paraduodenal mass was cytoplasmic and appeared non-specific. Lesions were consistent with renal PKD-like disease and a pancreatic cystic hamartoma.
Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans) / M. Tecilla, M. Bielli, F.C. Origgi. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 164(2018 Oct), pp. 44-47.
|Titolo:||Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans)|
TECILLA, MARCO (Primo) (Corresponding)
|Parole Chiave:||kidneypancreaspolycystic kidney-like diseaseturtle|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||ott-2018|
|Data ahead of print / Data di stampa:||23-set-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jcpa.2018.08.006|
|Appare nelle tipologie:||01 - Articolo su periodico|