A 62-year-old Caucasian man is described who developed acute kidney injury (AKI) and gross hematuria after a course with amoxycillin. At admission, urinalysis showed mild proteinuria, marked microscopic hematuria and cylindruria, which also included red blood cell casts. At renal biopsy an acute interstitial nephritis (AIN) was found, which was associated with many intratubular red blood cells and red blood cell casts, consequent acute tubular injury and red blood cell phagocytosis by tubular cells. After a course with corticosteroids, renal function partly recovered. This case demonstrates that red blood cell cylinclruria, red blood cell intratubular casts and red blood cell-induced tubular injury can also be observed in patients with acute interstitial nephritis and not only in patients with glomerulonephritis as described so far.
|Titolo:||Acute interstitial nephritis after amoxycillin with hematuria, red blood cell casts and hematuriainduced acute tubular injury|
|Parole Chiave:||acute interstitial nephritis; acute tubular necrosis; acute kidney injury; hematuria; red blood cell casts; red blood cell phagocytosis|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||10.5414/CN107179|
|Appare nelle tipologie:||01 - Articolo su periodico|