A lys-GTAGATCACT-lys peptide nucleic acid (PNA) decamer labelled with the luminescent 2,3-diphenyl maleimido (DPM) group on the ε-position of the terminal lysine residue was prepared through an automated solid phase synthesis. Fluorescence emission of the DPM-labelled PNA thus obtained was found to be significant and promising for the potential application in DNA recognition.

Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers / P. Ramani, S. Cauteruccio, E. Licandro, C. Baldoli. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 59:23(2018 Jun 06), pp. 2229-2231.

Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers

P. Ramani
Primo
;
S. Cauteruccio
Secondo
;
E. Licandro
Penultimo
;
2018

Abstract

A lys-GTAGATCACT-lys peptide nucleic acid (PNA) decamer labelled with the luminescent 2,3-diphenyl maleimido (DPM) group on the ε-position of the terminal lysine residue was prepared through an automated solid phase synthesis. Fluorescence emission of the DPM-labelled PNA thus obtained was found to be significant and promising for the potential application in DNA recognition.
Amino acids; Luminescence; Maleimides; Peptide nucleic acids; Solid phase synthesis; Biochemistry; Drug Discovery3003 Pharmaceutical Science; Organic Chemistry
Settore CHIM/06 - Chimica Organica
6-giu-2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0040403918303745-main (1).pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 461.93 kB
Formato Adobe PDF
461.93 kB Adobe PDF Visualizza/Apri
1-s2.0-S0040403918303745-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 623.78 kB
Formato Adobe PDF
623.78 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/590482
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact