International guidelines suggest a limited bundle of tests to investigate Bx etiology. We aimed to evaluate an extensive bundle performed on every patient to increase the chances to identify a treatable etiology. A prospective, observational study was conducted at Policlinico Hospital in Milan, Italy, from 2014 to 2017. All consecutive adults with Bx underwent the following tests: CBC, Aspergillus IgG and IgE, serum electrophoresis, sweat test and genetics for cystic fibrosis, immunoglobulins, IgG subclasses, lymphocytes subsets, nasal NO, autoantibodies, serum level and genetics for alpha1-antitrypsin deficiency (AATD). Bx etiologies identified based on the results of this extensive bundle were compared to etiologies identified based on the results of tests suggested by the BTS 2010 guidelines. Treatable etiologies were considered according to Lonni (Ann Am Thorac Soc 2015).

An extensive bundle of tests is needed to detect treatable causes of bronchiectasis (Bx) / E. Franceschi, A. Aliberti, M. Seia, L. Porcaro, V. Bianchi, E. Consalvo, A. Corsico, I. Ferrarotti, M. Gaffuri, L. Roncoroni, B. Vigone, A. Gramegna, M. Contarini, F. Amati, N. Borsa, F. Nava, N. Vanoni, A. Bellofiore, C. Del Monaco, L. Terranova, M. Oriano, L. Cariani, F. Caprioli, M. Nosotti, F. Blasi. ((Intervento presentato al 28. convegno ERS International Congress tenutosi a Paris nel 2018.

An extensive bundle of tests is needed to detect treatable causes of bronchiectasis (Bx)

M. Gaffuri;A. Gramegna;L. Terranova;M. Oriano;F. Caprioli;M. Nosotti;F. Blasi
2018

Abstract

International guidelines suggest a limited bundle of tests to investigate Bx etiology. We aimed to evaluate an extensive bundle performed on every patient to increase the chances to identify a treatable etiology. A prospective, observational study was conducted at Policlinico Hospital in Milan, Italy, from 2014 to 2017. All consecutive adults with Bx underwent the following tests: CBC, Aspergillus IgG and IgE, serum electrophoresis, sweat test and genetics for cystic fibrosis, immunoglobulins, IgG subclasses, lymphocytes subsets, nasal NO, autoantibodies, serum level and genetics for alpha1-antitrypsin deficiency (AATD). Bx etiologies identified based on the results of this extensive bundle were compared to etiologies identified based on the results of tests suggested by the BTS 2010 guidelines. Treatable etiologies were considered according to Lonni (Ann Am Thorac Soc 2015).
Settore MED/21 - Chirurgia Toracica
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
An extensive bundle of tests is needed to detect treatable causes of bronchiectasis (Bx) / E. Franceschi, A. Aliberti, M. Seia, L. Porcaro, V. Bianchi, E. Consalvo, A. Corsico, I. Ferrarotti, M. Gaffuri, L. Roncoroni, B. Vigone, A. Gramegna, M. Contarini, F. Amati, N. Borsa, F. Nava, N. Vanoni, A. Bellofiore, C. Del Monaco, L. Terranova, M. Oriano, L. Cariani, F. Caprioli, M. Nosotti, F. Blasi. ((Intervento presentato al 28. convegno ERS International Congress tenutosi a Paris nel 2018.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/589239
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