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Vascular endothelial growth factor (VEGF) genotypes, haplotypes and risk of bladder cancer / F. Longo, M.L. Biondi, V. Inneo, E. Itri, M. Murano, R. Pacciolla, A. Del Nero, B. Mangiarotti, E. Montanari. - In: EUROPEAN UROLOGY. SUPPLEMENTS. - ISSN 1569-9056. - 8:4(2009), pp. 227-227. ((Intervento presentato al 24. convegno Annual EAU Congress tenutosi a Stoccolma nel 2009.

Vascular endothelial growth factor (VEGF) genotypes, haplotypes and risk of bladder cancer

E. Montanari
Ultimo
2009
INTRODUCTION & OBJECTIVES: The vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving tumor growth and metastasis. Polymorphisms in VEGF gene may regulate VEGF production. In this case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G,+936C/T) in the VEGF gene are associated with the higher risk of developing a bladder cancer. MATERIAL & METHODS: VEGF genotypes and haplotypes were determined in 46 patients 36 male and 10 female, medium age 70 (range 51 – 91) with bladder cancer and 100 healthy controls. 42 patients have no muscle invasive bladder cancer, (29 high grade and 13 low grade) only 4 patients present muscle invasive bladder tumour. RESULTS: There were no associations between –460C/T and +405 C/G genotypes and the risk of bladder cancer. The combined +936 TT+ CT genotype was significantly associated with increased risk of cancer (OR 2.16; % CI 0.97-4.85; p=0.034). In haplotypes analysis the –460T/+405G/+936T haplotype was significantly (p=0.001) associated with increased risk of bladder cancer when compared with the most common CGC haplotype (OR 5.38; %CI 2.28-12.81). CONCLUSIONS: In conclusion, VEGF polymorphism in our study was involved in bladder cancer susceptibility. Further work is required to replicate these findings in a larger population and to correlate VEGF polymorphism with progression and recurrence of bladder cancer
Settore MED/24 - Urologia
2009
European Association of Urology
http://download.journals.elsevierhealth.com/pdfs/journals/1569-9056/PIIS1569905609604279.pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/58859
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