Tyrosine nitration of proteins is emerging as a post-translational modification playing a role in physiological conditions. Looking for the molecular events triggered by nitric oxide in nerve growth factor-induced neuronal differentiation, we now find that nitration occurs on the microtubule-associated protein tau In differentiated PC12 cells, we have identified as tau a nitrated protein that co-immunoprecipitates with alpha-tubulin and indicated that modified protein is associated with the cytoskeleton but it is confined to a restricted cell region. This paper supplies the first evidence that nitation of occurs in a physiological process and suggests that it could play a role in neuronal differentiation.
|Titolo:||The nitration of τ protein in neurone-like PC12 cells|
|Autori interni:||TEDESCHI, GABRIELLA|
MAGGIONI, MARIA GRAZIA
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore BIO/06 - Anatomia Comparata e Citologia
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1016/S0014-5793(04)00173-5|
|Appare nelle tipologie:||01 - Articolo su periodico|
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