Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.
Magnetic Hyperthermia and Radiation Therapy : Radiobiological Principles and Current Practice / S.V. Spirou, M. Basini, A. Lascialfari, C. Sangregorio, C. Innocenti. - In: NANOMATERIALS. - ISSN 2079-4991. - 8:6(2018), pp. 401.1-401.22.
|Titolo:||Magnetic Hyperthermia and Radiation Therapy : Radiobiological Principles and Current Practice|
|Parole Chiave:||cancer therapy; hyperthermia; magnetic fluid hyperthermia; magnetic nanoparticles; nanomedicine; radiation therapy|
|Settore Scientifico Disciplinare:||Settore FIS/01 - Fisica Sperimentale|
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore FIS/03 - Fisica della Materia
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nano8060401|
|Appare nelle tipologie:||01 - Articolo su periodico|