Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.

Magnetic Hyperthermia and Radiation Therapy : Radiobiological Principles and Current Practice / S.V. Spirou, M. Basini, A. Lascialfari, C. Sangregorio, C. Innocenti. - In: NANOMATERIALS. - ISSN 2079-4991. - 8:6(2018), pp. 401.1-401.22. [10.3390/nano8060401]

Magnetic Hyperthermia and Radiation Therapy : Radiobiological Principles and Current Practice

M. Basini;A. Lascialfari;
2018

Abstract

Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.
cancer therapy; hyperthermia; magnetic fluid hyperthermia; magnetic nanoparticles; nanomedicine; radiation therapy
Settore FIS/01 - Fisica Sperimentale
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore FIS/03 - Fisica della Materia
2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
nanomaterials-08-00401.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 341.96 kB
Formato Adobe PDF
341.96 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/586668
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 111
  • ???jsp.display-item.citation.isi??? 97
social impact