Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Malta, T.M.; Sokolov, A.; Gentles, A.J.; Burzykowski, T.; Poisson, L.; Weinstein, J.N.; Kamińska, B.; Huelsken, J.; Omberg, L.; Gevaert, O.; Colaprico, A.; Czerwińska, P.; Mazurek, S.; Mishra, L.; Heyn, H.; Krasnitz, A.; Godwin, A.K.; Lazar, A.J.; Caesar-Johnson, S.J.; Demchok, J.A.; Felau, I.; Kasapi, M.; Ferguson, M.L.; Hutter, C.M.; Sofia, H.J.; Tarnuzzer, R.; Wang, Z.; Yang, L.; Zenklusen, J.C.; Zhang, J.(.; Chudamani, S.; Liu, J.; Lolla, L.; Naresh, R.; Pihl, T.; Sun, Q.; Wan, Y.; Ye, W.; Cho, J.; Defreitas, T.; Frazer, S.; Gehlenborg, N.; Getz, G.; Heiman, D.I.; Kim, J.; Lawrence, M.S.; Lin, P.; Meier, S.; Noble, M.S.; Saksena, G.; Voet, D.; Zhang, H.; Bernard, B.; Chambwe, N.; Dhankani, V.; Knijnenburg, T.; Kramer, R.; Leinonen, K.; Liu, Y.; Miller, M.; Reynolds, S.; Shmulevich, I.; Thorsson, V.; Zhang, W.; Akbani, R.; Broom, B.M.; Hegde, A.M.; Zhenlin, J.; Kanchi, R.S.; Korkut, A.; Jun, L.; Liang, H.; Ling, S.; Liu, W.; Yiling, L.; Mills, G.B.; Kwok-Shing, N.; Rao, A.; Ryan, M.; Wang, J.; Weinstein, J.N.; Zhang, J.; Abeshouse, A.; Armenia, J.; Chakravarty, D.; Chatila, W.K.; de Bruijn, I.; Gao, J.; Gross, B.E.; Heins, Z.J.; Kundra, R.; Konnor, L.; Ladanyi, M.; Luna, A.; Nissan, M.G.; Ochoa, A.; Phillips, S.M.; Reznik, E.; Sanchez-Vega, F.; Sander, C.; Schultz, N.; Sheridan, R.; Sumer, S.O.; Sun, Y.; Taylor, B.S.; Wang, J.; Zhang, H.; Anur, P.; Peto, M.; Spellman, P.; Benz, C.; Stuart, J.M.; Wong, C.K.; Yau, C.; Hayes, D.N.; Parker, J.S.; Wilkerson, M.D.; Ally, A.; Balasundaram, M.; Bowlby, R.; Brooks, D.; Carlsen, R.; Chuah, E.; Dhalla, N.; Holt, R.; Jones, S.J.M.; Kasaian, K.; Lee, D.; Yussanne, M.; Marra, M.A.; Mayo, M.; Moore, R.A.; Mungall, A.J.; Mungall, K.; Robertson, A.G.; Sadeghi, S.; Schein, J.E.; Sipahimalani, P.; Tam, A.; Thiessen, N.; Tse, K.; Wong, T.; Berger, A.C.; Beroukhim, R.; Cherniack, A.D.; Cibulskis, C.; Gabriel, S.B.; Gao, G.F.; Gavin, H.; Meyerson, M.; Schumacher, S.E.; Shih, J.; Kucherlapati, M.H.; Kucherlapati, R.S.; Baylin, S.; Cope, L.; Danilova, L.; Bootwalla, M.S.; Lai, P.H.; Maglinte, D.T.; Van Den Berg, D.J.; Weisenberger, D.J.; Auman, J.T.; Balu, S.; Bodenheimer, T.; Fan, C.; Hoadley, K.A.; Hoyle, A.P.; Jefferys, S.R.; Jones, C.D.; Meng, S.; Mieczkowski, P.A.; Mose, L.E.; Perou, A.H.; Perou, C.M.; Roach, J.; Shi, Y.; Simons, J.V.; Skelly, T.; Soloway, M.G.; Tan, D.; Veluvolu, U.; Fan, H.; Hinoue, T.; Laird, P.W.; Shen, H.; Zhou, W.; Bellair, M.; Chang, K.; Covington, K.; Creighton, C.J.; Dinh, H.; Doddapaneni, H.; Donehower, L.A.; Drummond, J.; Gibbs, R.A.; Glenn, R.; Hale, W.; Han, Y.; Jianhong, H.; Korchina, V.; Lee, S.; Lewis, L.; Wei, L.; Liu, X.; Morgan, M.; Morton, D.; Muzny, D.; Santibanez, J.; Sheth, M.; Shinbrot, E.; Wang, L.; Wang, M.; Wheeler, D.A.; Liu, X.; Zhao, F.; Hess, J.; Appelbaum, E.L.; Bailey, M.; Cordes, M.G.; Ding, L.; Fronick, C.C.; Fulton, L.A.; Fulton, R.S.; Kandoth, C.; Mardis, E.R.; Mclellan, M.D.; Miller, C.A.; Schmidt, H.K.; Wilson, R.K.; Crain, D.; Curley, E.; Gardner, J.; Lau, K.; Mallery, D.; Morris, S.; Paulauskis, J.; Penny, R.; Shelton, C.; Shelton, T.; Sherman, M.; Thompson, E.; Yena, P.; Bowen, J.; Gastier-Foster, J.M.; Gerken, M.; Leraas, K.M.; Lichtenberg, T.M.; Ramirez, N.C.; Wise, L.; Zmuda, E.; Corcoran, N.; Costello, T.; Hovens, C.; Carvalho, A.L.; de Carvalho, A.C.; Fregnani, J.H.; Longatto-Filho, A.; Reis, R.M.; Scapulatempo-Neto, C.; Silveira, H.C.S.; Vidal, D.O.; Burnette, A.; Eschbacher, J.; Hermes, B.; Noss, A.; Singh, R.; Anderson, M.L.; Castro, P.D.; Ittmann, M.; Huntsman, D.; Kohl, B.; Xuan, L.; Thorp, R.; Andry, C.; Duffy, E.R.; Lyadov, V.; Paklina, O.; Setdikova, G.; Shabunin, A.; Tavobilov, M.; Mcpherson, C.; Warnick, R.; Berkowitz, R.; Cramer, D.; Feltmate, C.; Horowitz, N.; Kibel, A.; Muto, M.; Raut, C.P.; Malykh, A.; Barnholtz-Sloan, J.S.; Barrett, W.; Devine, K.; Fulop, J.; Ostrom, Q.T.; Shimmel, K.; Wolinsky, Y.; Sloan, A.E.; De Rose, A.; Giuliante, F.; Goodman, M.; Karlan, B.Y.; Hagedorn, C.H.; Eckman, J.; Harr, J.; Myers, J.; Tucker, K.; Zach, L.A.; Deyarmin, B.; Hai, H.; Kvecher, L.; Larson, C.; Mural, R.J.; Somiari, S.; Vicha, A.; Zelinka, T.; Bennett, J.; Iacocca, M.; Rabeno, B.; Swanson, P.; Latour, M.; Lacombe, L.; Têtu, B.; Bergeron, A.; Mcgraw, M.; Staugaitis, S.M.; Chabot, J.; Hibshoosh, H.; Sepulveda, A.; Tao, S.; Wang, T.; Potapova, O.; Voronina, O.; Desjardins, L.; Mariani, O.; Roman-Roman, S.; Sastre, X.; Stern, M.; Cheng, F.; Signoretti, S.; Berchuck, A.; Bigner, D.; Lipp, E.; Marks, J.; Mccall, S.; Mclendon, R.; Secord, A.; Sharp, A.; Behera, M.; Brat, D.J.; Chen, A.; Delman, K.; Force, S.; Khuri, F.; Magliocca, K.; Maithel, S.; Olson, J.J.; Owonikoko, T.; Pickens, A.; Ramalingam, S.; Shin, D.M.; Sica, G.; Van Meir, E.G.; Zhang, H.; Eijckenboom, W.; Gillis, A.; Korpershoek, E.; Looijenga, L.; Oosterhuis, W.; Stoop, H.; van Kessel, K.E.; Zwarthoff, E.C.; Calatozzolo, C.; Cuppini, L.; Cuzzubbo, S.; Dimeco, F.; Finocchiaro, G.; Mattei, L.; Perin, A.; Pollo, B.; Chen, C.; Houck, J.; Lohavanichbutr, P.; Hartmann, A.; Stoehr, C.; Stoehr, R.; Taubert, H.; Wach, S.; Wullich, B.; Kycler, W.; Murawa, D.; Wiznerowicz, M.; Chung, K.; Edenfield, W.J.; Martin, J.; Baudin, E.; Bubley, G.; Bueno, R.; De Rienzo, A.; Richards, W.G.; Kalkanis, S.; Mikkelsen, T.; Noushmehr, H.; Scarpace, L.; Girard, N.; Aymerich, M.; Campo, E.; Giné, E.; Guillermo, A.L.; Van Bang, N.; Hanh, P.T.; Phu, B.D.; Tang, Y.; Colman, H.; Evason, K.; Dottino, P.R.; Martignetti, J.A.; Gabra, H.; Juhl, H.; Akeredolu, T.; Stepa, S.; Hoon, D.; Ahn, K.; Kang, K.J.; Beuschlein, F.; Breggia, A.; Birrer, M.; Bell, D.; Borad, M.; Bryce, A.H.; Castle, E.; Chandan, V.; Cheville, J.; Copland, J.A.; Farnell, M.; Flotte, T.; Giama, N.; Thai, H.; Kendrick, M.; Kocher, J.; Kopp, K.; Moser, C.; Nagorney, D.; O'Brien, D.; O'Neill, B.P.; Patel, T.; Petersen, G.; Que, F.; Rivera, M.; Roberts, L.; Smallridge, R.; Smyrk, T.; Stanton, M.; Thompson, R.H.; Torbenson, M.; Yang, J.D.; Zhang, L.; Brimo, F.; Ajani, J.A.; Gonzalez, A.M.A.; Behrens, C.; Bondaruk, J.; Broaddus, R.; Czerniak, B.; Esmaeli, B.; Fujimoto, J.; Gershenwald, J.; Guo, C.; Lazar, A.J.; Logothetis, C.; Meric-Bernstam, F.; Moran, C.; Ramondetta, L.; Rice, D.; Sood, A.; Tamboli, P.; Thompson, T.; Troncoso, P.; Tsao, A.; Wistuba, I.; Carter, C.; Haydu, L.; Hersey, P.; Jakrot, V.; Kakavand, H.; Kefford, R.; Lee, K.; Long, G.; Mann, G.; Quinn, M.; Saw, R.; Scolyer, R.; Shannon, K.; Spillane, A.; Stretch, J.; Synott, M.; Thompson, J.; Wilmott, J.; Al-Ahmadie, H.; Chan, T.A.; Ghossein, R.; Gopalan, A.; Levine, D.A.; Reuter, V.; Singer, S.; Singh, B.; Tien, N.V.; Broudy, T.; Mirsaidi, C.; Nair, P.; Drwiega, P.; Miller, J.; Smith, J.; Zaren, H.; Park, J.; Hung, N.P.; Kebebew, E.; Linehan, W.M.; Metwalli, A.R.; Pacak, K.; Pinto, P.A.; Schiffman, M.; Schmidt, L.S.; Vocke, C.D.; Wentzensen, N.; Worrell, R.; Yang, H.; Moncrieff, M.; Goparaju, C.; Melamed, J.; Pass, H.; Botnariuc, N.; Caraman, I.; Cernat, M.; Chemencedji, I.; Clipca, A.; Doruc, S.; Gorincioi, G.; Mura, S.; Pirtac, M.; Stancul, I.; Tcaciuc, D.; Albert, M.; Alexopoulou, I.; Arnaout, A.; Bartlett, J.; Engel, J.; Gilbert, S.; Parfitt, J.; Sekhon, H.; Thomas, G.; Rassl, D.M.; Rintoul, R.C.; Bifulco, C.; Tamakawa, R.; Urba, W.; Hayward, N.; Timmers, H.; Antenucci, A.; Facciolo, F.; Grazi, G.; Marino, M.; Merola, R.; de Krijger, R.; Gimenez-Roqueplo, A.; Piché, A.; Chevalier, S.; Mckercher, G.; Birsoy, K.; Barnett, G.; Brewer, C.; Farver, C.; Naska, T.; Pennell, N.A.; Raymond, D.; Schilero, C.; Smolenski, K.; Williams, F.; Morrison, C.; Borgia, J.A.; Liptay, M.J.; Pool, M.; Seder, C.W.; Junker, K.; Omberg, L.; Dinkin, M.; Manikhas, G.; Alvaro, D.; Bragazzi, M.C.; Cardinale, V.; Carpino, G.; Gaudio, E.; Chesla, D.; Cottingham, S.; Dubina, M.; Moiseenko, F.; Dhanasekaran, R.; Becker, K.; Janssen, K.; Slotta-Huspenina, J.; Abdel-Rahman, M.H.; Aziz, D.; Bell, S.; Cebulla, C.M.; Davis, A.; Duell, R.; Elder, J.B.; Hilty, J.; Kumar, B.; Lang, J.; Lehman, N.L.; Mandt, R.; Nguyen, P.; Pilarski, R.; Rai, K.; Schoenfield, L.; Senecal, K.; Wakely, P.; Hansen, P.; Lechan, R.; Powers, J.; Tischler, A.; Grizzle, W.E.; Sexton, K.C.; Kastl, A.; Henderson, J.; Porten, S.; Waldmann, J.; Fassnacht, M.; Asa, S.L.; Schadendorf, D.; Couce, M.; Graefen, M.; Huland, H.; Sauter, G.; Schlomm, T.; Simon, R.; Tennstedt, P.; Olabode, O.; Nelson, M.; Bathe, O.; Carroll, P.R.; Chan, J.M.; Disaia, P.; Glenn, P.; Kelley, R.K.; Landen, C.N.; Phillips, J.; Prados, M.; Simko, J.; Smith-McCune, K.; Vandenberg, S.; Roggin, K.; Fehrenbach, A.; Kendler, A.; Sifri, S.; Steele, R.; Jimeno, A.; Carey, F.; Forgie, I.; Mannelli, M.; Carney, M.; Hernandez, B.; Campos, B.; Herold-Mende, C.; Jungk, C.; Unterberg, A.; von Deimling, A.; Bossler, A.; Galbraith, J.; Jacobus, L.; Knudson, M.; Knutson, T.; Deqin, M.; Milhem, M.; Sigmund, R.; Godwin, A.K.; Madan, R.; Rosenthal, H.G.; Adebamowo, C.; Adebamowo, S.N.; Boussioutas, A.; Beer, D.; Giordano, T.; Mes-Masson, A.; Saad, F.; Bocklage, T.; Landrum, L.; Mannel, R.; Moore, K.; Moxley, K.; Postier, R.; Walker, J.; Zuna, R.; Feldman, M.; Valdivieso, F.; Dhir, R.; Luketich, J.; Pinero, E.M.M.; Quintero-Aguilo, M.; Carlotti, C.G.; Dos Santos, J.S.; Kemp, R.; Sankarankuty, A.; Tirapelli, D.; Catto, J.; Agnew, K.; Swisher, E.; Creaney, J.; Robinson, B.; Shelley, C.S.; Godwin, E.M.; Kendall, S.; Shipman, C.; Bradford, C.; Carey, T.; Haddad, A.; Moyer, J.; Peterson, L.; Prince, M.; Rozek, L.; Wolf, G.; Bowman, R.; Fong, K.M.; Yang, I.; Korst, R.; Rathmell, W.K.; Fantacone-Campbell, J.L.; Hooke, J.A.; Kovatich, A.J.; Shriver, C.D.; Dipersio, J.; Drake, B.; Govindan, R.; Heath, S.; Ley, T.; Van Tine, B.; Westervelt, P.; Rubin, M.A.; Lee, J.I.; Aredes, N.D.; Mariamidze, A.; Stuart, J.M.; Hoadley, K.A.; Laird, P.W.; Noushmehr, H.; Wiznerowicz, M.

doi:10.1016/j.cell.2018.03.034

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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

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Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. Using OCLR, we were able to identify previously undiscovered biological mechanisms associated with the dedifferentiated oncogenic state. Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune cells. We found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors. Application of our stemness indices to single-cell data revealed patterns of intra-tumor molecular heterogeneity. Finally, the indices allowed for the identification of novel targets and possible targeted therapies aimed at tumor differentiation.

Titolo:	Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Autori:	Malta, Tathiane M. Sokolov, Artem Gentles, Andrew J. Burzykowski, Tomasz Poisson, Laila Weinstein, John N. Kamińska, Bożena Huelsken, Joerg Omberg, Larsson Gevaert, Olivier Colaprico, Antonio Czerwińska, Patrycja Mazurek, Sylwia Mishra, Lopa Heyn, Holger Krasnitz, Alex Godwin, Andrew K. Lazar, Alexander J. Caesar-Johnson, Samantha J. Demchok, John A. Felau, Ina Kasapi, Melpomeni Ferguson, Martin L. Hutter, Carolyn M. Sofia, Heidi J. Tarnuzzer, Roy Wang, Zhining Yang, Liming Zenklusen, Jean C. Zhang, Jiashan (Julia) Chudamani, Sudha Liu, Jia Lolla, Laxmi Naresh, Rashi Pihl, Todd Sun, Qiang Wan, Yunhu Wu, Ye Cho, Juok DeFreitas, Timothy Frazer, Scott Gehlenborg, Nils Getz, Gad Heiman, David I. Kim, Jaegil Lawrence, Michael S. Lin, Pei Meier, Sam Noble, Michael S. Saksena, Gordon Voet, Doug Zhang, Hailei Bernard, Brady Chambwe, Nyasha Dhankani, Varsha Knijnenburg, Theo Kramer, Roger Leinonen, Kalle Liu, Yuexin Miller, Michael Reynolds, Sheila Shmulevich, Ilya Thorsson, Vesteinn Zhang, Wei Akbani, Rehan Broom, Bradley M. Hegde, Apurva M. Ju, Zhenlin Kanchi, Rupa S. Korkut, Anil Li, Jun Liang, Han Ling, Shiyun Liu, Wenbin Lu, Yiling Mills, Gordon B. Ng, Kwok-Shing Rao, Arvind Ryan, Michael Wang, Jing Weinstein, John N. Zhang, Jiexin Abeshouse, Adam Armenia, Joshua Chakravarty, Debyani Chatila, Walid K. de Bruijn, Ino Gao, Jianjiong Gross, Benjamin E. Heins, Zachary J. Kundra, Ritika La, Konnor Ladanyi, Marc Luna, Augustin Nissan, Moriah G. Ochoa, Angelica Phillips, Sarah M. Reznik, Ed Sanchez-Vega, Francisco Sander, Chris Schultz, Nikolaus Sheridan, Robert Sumer, S. Onur Sun, Yichao Taylor, Barry S. Wang, Jioajiao Zhang, Hongxin Anur, Pavana Peto, Myron Spellman, Paul Benz, Christopher Stuart, Joshua M. Wong, Christopher K. Yau, Christina Hayes, D. Neil Parker, Joel S. Wilkerson, Matthew D. Ally, Adrian Balasundaram, Miruna Bowlby, Reanne Brooks, Denise Carlsen, Rebecca Chuah, Eric Dhalla, Noreen Holt, Robert Jones, Steven J. M. Kasaian, Katayoon Lee, Darlene Ma, Yussanne Marra, Marco A. Mayo, Michael Moore, Richard A. Mungall, Andrew J. Mungall, Karen Robertson, A. Gordon Sadeghi, Sara Schein, Jacqueline E. Sipahimalani, Payal Tam, Angela Thiessen, Nina Tse, Kane Wong, Tina Berger, Ashton C. Beroukhim, Rameen Cherniack, Andrew D. Cibulskis, Carrie Gabriel, Stacey B. Gao, Galen F. Ha, Gavin Meyerson, Matthew Schumacher, Steven E. Shih, Juliann Kucherlapati, Melanie H. Kucherlapati, Raju S. Baylin, Stephen Cope, Leslie Danilova, Ludmila Bootwalla, Moiz S. Lai, Phillip H. Maglinte, Dennis T. Van Den Berg, David J. Weisenberger, Daniel J. Auman, J. Todd Balu, Saianand Bodenheimer, Tom Fan, Cheng Hoadley, Katherine A. Hoyle, Alan P. Jefferys, Stuart R. Jones, Corbin D. Meng, Shaowu Mieczkowski, Piotr A. Mose, Lisle E. Perou, Amy H. Perou, Charles M. Roach, Jeffrey Shi, Yan Simons, Janae V. Skelly, Tara Soloway, Matthew G. Tan, Donghui Veluvolu, Umadevi Fan, Huihui Hinoue, Toshinori Laird, Peter W. Shen, Hui Zhou, Wanding Bellair, Michelle Chang, Kyle Covington, Kyle Creighton, Chad J. Dinh, Huyen Doddapaneni, HarshaVardhan Donehower, Lawrence A. Drummond, Jennifer Gibbs, Richard A. Glenn, Robert Hale, Walker Han, Yi Hu, Jianhong Korchina, Viktoriya Lee, Sandra Lewis, Lora Li, Wei Liu, Xiuping Morgan, Margaret Morton, Donna Muzny, Donna Santibanez, Jireh Sheth, Margi Shinbrot, Eve Wang, Linghua Wang, Min Wheeler, David A. Xi, Liu Zhao, Fengmei Hess, Julian Appelbaum, Elizabeth L. Bailey, Matthew Cordes, Matthew G. Ding, Li Fronick, Catrina C. Fulton, Lucinda A. Fulton, Robert S. Kandoth, Cyriac Mardis, Elaine R. McLellan, Michael D. Miller, Christopher A. Schmidt, Heather K. Wilson, Richard K. Crain, Daniel Curley, Erin Gardner, Johanna Lau, Kevin Mallery, David Morris, Scott Paulauskis, Joseph Penny, Robert Shelton, Candace Shelton, Troy Sherman, Mark Thompson, Eric Yena, Peggy Bowen, Jay Gastier-Foster, Julie M. Gerken, Mark Leraas, Kristen M. Lichtenberg, Tara M. Ramirez, Nilsa C. Wise, Lisa Zmuda, Erik Corcoran, Niall Costello, Tony Hovens, Christopher Carvalho, Andre L. de Carvalho, Ana C. Fregnani, José H. Longatto-Filho, Adhemar Reis, Rui M. Scapulatempo-Neto, Cristovam Silveira, Henrique C. S. Vidal, Daniel O. Burnette, Andrew Eschbacher, Jennifer Hermes, Beth Noss, Ardene Singh, Rosy Anderson, Matthew L. Castro, Patricia D. Ittmann, Michael Huntsman, David Kohl, Bernard Le, Xuan Thorp, Richard Andry, Chris Duffy, Elizabeth R. Lyadov, Vladimir Paklina, Oxana Setdikova, Galiya Shabunin, Alexey Tavobilov, Mikhail McPherson, Christopher Warnick, Ronald Berkowitz, Ross Cramer, Daniel Feltmate, Colleen Horowitz, Neil Kibel, Adam Muto, Michael Raut, Chandrajit P. Malykh, Andrei Barnholtz-Sloan, Jill S. Barrett, Wendi Devine, Karen Fulop, Jordonna Ostrom, Quinn T. Shimmel, Kristen Wolinsky, Yingli Sloan, Andrew E. De Rose, Agostino Giuliante, Felice Goodman, Marc Karlan, Beth Y. Hagedorn, Curt H. Eckman, John Harr, Jodi Myers, Jerome Tucker, Kelinda Zach, Leigh Anne Deyarmin, Brenda Hu, Hai Kvecher, Leonid Larson, Caroline Mural, Richard J. Somiari, Stella Vicha, Ales Zelinka, Tomas Bennett, Joseph Iacocca, Mary Rabeno, Brenda Swanson, Patricia Latour, Mathieu Lacombe, Louis Têtu, Bernard Bergeron, Alain McGraw, Mary Staugaitis, Susan M. Chabot, John Hibshoosh, Hanina Sepulveda, Antonia Su, Tao Wang, Timothy Potapova, Olga Voronina, Olga Desjardins, Laurence Mariani, Odette Roman-Roman, Sergio Sastre, Xavier Stern, Marc-Henri Cheng, Feixiong Signoretti, Sabina Berchuck, Andrew Bigner, Darell Lipp, Eric Marks, Jeffrey McCall, Shannon McLendon, Roger Secord, Angeles Sharp, Alexis Behera, Madhusmita Brat, Daniel J. Chen, Amy Delman, Keith Force, Seth Khuri, Fadlo Magliocca, Kelly Maithel, Shishir Olson, Jeffrey J. Owonikoko, Taofeek Pickens, Alan Ramalingam, Suresh Shin, Dong M. Sica, Gabriel Van Meir, Erwin G. Zhang, Hongzheng Eijckenboom, Wil Gillis, Ad Korpershoek, Esther Looijenga, Leendert Oosterhuis, Wolter Stoop, Hans van Kessel, Kim E. Zwarthoff, Ellen C. Calatozzolo, Chiara Cuppini, Lucia Cuzzubbo, Stefania DI MECO, FRANCESCO [Membro del Collaboration Group] Finocchiaro, Gaetano Mattei, Luca Perin, Alessandro Pollo, Bianca Chen, Chu Houck, John Lohavanichbutr, Pawadee Hartmann, Arndt Stoehr, Christine Stoehr, Robert Taubert, Helge Wach, Sven Wullich, Bernd Kycler, Witold Murawa, Dawid Wiznerowicz, Maciej Chung, Ki Edenfield, W. Jeffrey Martin, Julie Baudin, Eric Bubley, Glenn Bueno, Raphael De Rienzo, Assunta Richards, William G. Kalkanis, Steven Mikkelsen, Tom Noushmehr, Houtan Scarpace, Lisa Girard, Nicolas Aymerich, Marta Campo, Elias Giné, Eva Guillermo, Armando López Van Bang, Nguyen Hanh, Phan Thi Phu, Bui Duc Tang, Yufang Colman, Howard Evason, Kimberley Dottino, Peter R. Martignetti, John A. Gabra, Hani Juhl, Hartmut Akeredolu, Teniola Stepa, Serghei Hoon, Dave Ahn, Keunsoo Kang, Koo Jeong Beuschlein, Felix Breggia, Anne Birrer, Michael Bell, Debra Borad, Mitesh Bryce, Alan H. Castle, Erik Chandan, Vishal Cheville, John Copland, John A. Farnell, Michael Flotte, Thomas Giama, Nasra Ho, Thai Kendrick, Michael Kocher, Jean-Pierre Kopp, Karla Moser, Catherine Nagorney, David O'Brien, Daniel O'Neill, Brian Patrick Patel, Tushar Petersen, Gloria Que, Florencia Rivera, Michael Roberts, Lewis Smallridge, Robert Smyrk, Thomas Stanton, Melissa Thompson, R. Houston Torbenson, Michael Yang, Ju Dong Zhang, Lizhi Brimo, Fadi Ajani, Jaffer A. Gonzalez, Ana Maria Angulo Behrens, Carmen Bondaruk, Jolanta Broaddus, Russell Czerniak, Bogdan Esmaeli, Bita Fujimoto, Junya Gershenwald, Jeffrey Guo, Charles Lazar, Alexander J. Logothetis, Christopher Meric-Bernstam, Funda Moran, Cesar Ramondetta, Lois Rice, David Sood, Anil Tamboli, Pheroze Thompson, Timothy Troncoso, Patricia Tsao, Anne Wistuba, Ignacio Carter, Candace Haydu, Lauren Hersey, Peter Jakrot, Valerie Kakavand, Hojabr Kefford, Richard Lee, Kenneth Long, Georgina Mann, Graham Quinn, Michael Saw, Robyn Scolyer, Richard Shannon, Kerwin Spillane, Andrew Stretch, Jonathan Synott, Maria Thompson, John Wilmott, James Al-Ahmadie, Hikmat Chan, Timothy A. Ghossein, Ronald Gopalan, Anuradha Levine, Douglas A. Reuter, Victor Singer, Samuel Singh, Bhuvanesh Tien, Nguyen Viet Broudy, Thomas Mirsaidi, Cyrus Nair, Praveen Drwiega, Paul Miller, Judy Smith, Jennifer Zaren, Howard Park, Joong-Won Hung, Nguyen Phi Kebebew, Electron Linehan, W. Marston Metwalli, Adam R. 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Mariamidze, Armaz Stuart, Joshua M. Hoadley, Katherine A. Laird, Peter W. Noushmehr, Houtan Wiznerowicz, Maciej mostra contributor esterni nascondi contributor esterni
Parole Chiave:	cancer stem cells; dedifferentiation; epigenomic; genomic; machine learning; pan-cancer; stemness; The Cancer Genome Atlas; Biochemistry, Genetics and Molecular Biology (all)
Settore Scientifico Disciplinare:	Settore MED/27 - Neurochirurgia
Data di pubblicazione:	5-apr-2018
Rivista:	CELL
Tipologia:	Article (author)
Digital Object Identifier (DOI):	10.1016/j.cell.2018.03.034
Appare nelle tipologie:	01 - Articolo su periodico

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Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.pdf		Publisher's version/PDF		Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2434/586511

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