Phycodnaviruses are dsDNA viruses, which infect algae. Their large genomes encode many gene products, like small K+channels, with homologs in prokaryotes and eukaryotes. Screening for K+channels revealed their abundance in viruses from fresh-water habitats. Recent sequencing of viruses from marine algae or from salt water in Antarctica revealed sequences with the predicted characteristics of K+channels but with some unexpected features. Two genes encode either 78 or 79 amino acid proteins, which are the smallest known K+channels. Also of interest is an unusual sequence in the canonical α-helixes in K+channels. Structural prediction algorithms indicate that the new channels have the conserved α-helix folds but the algorithms failed to identify the expected transmembrane domains flanking the K+channel pores. In spite of these unexpected properties electophysiological studies confirmed that the new proteins are functional K+channels.
|Titolo:||Viruses infecting marine picoplancton encode functional potassium ion channels|
|Parole Chiave:||K+ channel evolution; Kcv; Chlorella viruses; Algal viruses; Virus evolution|
|Settore Scientifico Disciplinare:||Settore BIO/04 - Fisiologia Vegetale|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||10.1016/j.virol.2014.05.002|
|Appare nelle tipologie:||01 - Articolo su periodico|