Objective: We aimed to study in SSc patients macrovascular involvement by using power Doppler ultrasound (PDUS) and microvascular one by PDUS and nailfold video-capillaroscopy (NVC) and to examine the association between history of digital ulcers (HDU) and imaging (PDUS and NVC) parameters. Methods: NVC and PDUS were systematically performed in 106 consecutive SSc patients at the 3rd and 4th finger of the dominant hand after exclusion of ulnar artery occlusion (UAO). 22 MHz PDUS measurements included nailbed and fingertip qualitatively graded, and resistivity index (RI) of ulnar and radial proper digital arteries. Capillary number/mm was calculated by NVC on the same digits examined by PDUS. Results: Vascularization at fingertip and nailbed showed a good correlation between them and to capillary number. RI, representative of macrovascular involvement, did not correlate to microvascular involvement as assessed by PDUS and NVC. RI and capillary number at NVC showed significant correlation to HDU while fingertip and nailbed vascularization as assessed by PDUS did not. As such, PDUS and NVC provide different and potentially complementary information on SSc-related peripheral macro- and micro-vascular involvement. Conclusion: Macro- and micro-vascular involvement in SSc patients are different processes and are not present at the same time in every patient. Thus, both these aspects should be carefully evaluated in SSc patients.
Evidence of macro- and micro-angiopathy in scleroderma: An integrated approach combining 22-MHz power Doppler ultrasonography and video-capillaroscopy / T. Schioppo, A. Orenti, P. Boracchi, O. De Lucia, A. Murgo, F. Ingegnoli. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 122(2019 Mar), pp. 125-130.
|Titolo:||Evidence of macro- and micro-angiopathy in scleroderma: An integrated approach combining 22-MHz power Doppler ultrasonography and video-capillaroscopy|
SCHIOPPO, TOMMASO (Primo)
ORENTI, ANNALISA (Secondo)
INGEGNOLI, FRANCESCA ANNA (Ultimo) (Corresponding)
|Parole Chiave:||Capillaroscopy; Iloprost; Raynaud's phenomenon; Systemic sclerosis; Ultrasound; Biochemistry; Cardiology and Cardiovascular Medicine; Cell Biology|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||mar-2019|
|Data ahead of print / Data di stampa:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.mvr.2018.07.001|
|Appare nelle tipologie:||01 - Articolo su periodico|