During my PhD, we focused our attention on the application of the green chemistry principles for the preparation of active pharmaceutical ingredients (API) and, more in general, of highly functionalized chiral molecules, as fine chemicals or building blocks of high value for further synthetic manipulations. Mainly the topics of our interest will be divided in three main chapters: 1- The use of a cheap and green reducing agent, HSiCl3, for imines reduction either in batch and flow mode. 2- The use of 3D-printed reactors for the preparation of APIs, engineering new reactors in order to perform continuous multi-step synthesis. 3- a) The use of iron complexes, the Knolker type, for the hydrogenations of chiral imines. b) The use of cheap and readily available Iron complex, Fe(hmds)2, for the trimerization of acetylenes, using for the first time a reducing agent free protocol.

SUSTAINABLE PREPARATION OF APIS IN BATCH&FLOW MODE, AND IRON CATALYZED TRANSFORMATIONS / D. Brenna ; tutor: M. Benaglia, E. Pizzotti. - : . Università degli Studi di Milano, 2018 Feb 01. ((30. ciclo, Anno Accademico 2017. [10.13130/brenna-davide_phd2018-02-01].

SUSTAINABLE PREPARATION OF APIS IN BATCH&FLOW MODE, AND IRON CATALYZED TRANSFORMATIONS

D. Brenna
2018

Abstract

During my PhD, we focused our attention on the application of the green chemistry principles for the preparation of active pharmaceutical ingredients (API) and, more in general, of highly functionalized chiral molecules, as fine chemicals or building blocks of high value for further synthetic manipulations. Mainly the topics of our interest will be divided in three main chapters: 1- The use of a cheap and green reducing agent, HSiCl3, for imines reduction either in batch and flow mode. 2- The use of 3D-printed reactors for the preparation of APIs, engineering new reactors in order to perform continuous multi-step synthesis. 3- a) The use of iron complexes, the Knolker type, for the hydrogenations of chiral imines. b) The use of cheap and readily available Iron complex, Fe(hmds)2, for the trimerization of acetylenes, using for the first time a reducing agent free protocol.
BENAGLIA, MAURIZIO
Imines; trichlorosilane; API; Iron; Catalysis; 3DPrinting; Stereoselective
Settore CHIM/06 - Chimica Organica
SUSTAINABLE PREPARATION OF APIS IN BATCH&FLOW MODE, AND IRON CATALYZED TRANSFORMATIONS / D. Brenna ; tutor: M. Benaglia, E. Pizzotti. - : . Università degli Studi di Milano, 2018 Feb 01. ((30. ciclo, Anno Accademico 2017. [10.13130/brenna-davide_phd2018-02-01].
Doctoral Thesis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/585122
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