Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
|Titolo:||La flunarizina nel trattamento delle arteriopatie degli arti inferiori|
CATALANO, MARIA [Writing – Original Draft Preparation] (Corresponding)
LIBRETTI, ARNALDO [Supervision]
|Parole Chiave:||Aged; Blood Viscosity; Calcium Channel Blockers; Cinnarizine; Double-Blind Method; Erythrocyte Deformability; Flunarizine; Humans; Intermittent Claudication; Middle Aged; Piperazines; Platelet Aggregation; Rheology|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||1985|
|Appare nelle tipologie:||01 - Articolo su periodico|