Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.

La flunarizina nel trattamento delle arteriopatie degli arti inferiori / M. Catalano, E. Sacchi, M. Tomasini, E. Coazzoli, A. Parolini, A. Dall'Oglio, A. Libretti. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 15:suppl. 1(1985), pp. 475-478.

La flunarizina nel trattamento delle arteriopatie degli arti inferiori

M. Catalano
Writing – Original Draft Preparation
;
A. Libretti
Supervision
1985

Abstract

Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
Aged; Blood Viscosity; Calcium Channel Blockers; Cinnarizine; Double-Blind Method; Erythrocyte Deformability; Flunarizine; Humans; Intermittent Claudication; Middle Aged; Piperazines; Platelet Aggregation; Rheology
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
1985
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/583536
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