Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
La flunarizina nel trattamento delle arteriopatie degli arti inferiori / M. Catalano, E. Sacchi, M. Tomasini, E. Coazzoli, A. Parolini, A. Dall'Oglio, A. Libretti. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 15:suppl. 1(1985), pp. 475-478.
La flunarizina nel trattamento delle arteriopatie degli arti inferiori
M. Catalano
Writing – Original Draft Preparation
;A. LibrettiSupervision
1985
Abstract
Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.File | Dimensione | Formato | |
---|---|---|---|
Flunarazina.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.81 MB
Formato
Adobe PDF
|
1.81 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.