Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may be a good target for the development of an antimalarial drug. This study presents data obtained with PM4s from several Plasmodium species. Low nanomolar K(i) values have been observed for all PM4s studied.
|Titolo:||Targeting the plasmepsin 4 orthologs of Plasmodium sp with "Double Drug" inhibitors|
ROMEO, SERGIO (Penultimo)
|Parole Chiave:||A combination of two molecular entities in one compound that kill a pathogen by two mechanisms; A word derived from plasmodium pepsin; Double drug; Plasmepsin; Proteolytic enzyme from the plasmodium species; Statine|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||10.2174/092986608785849218|
|Appare nelle tipologie:||01 - Articolo su periodico|