Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiological studies have identified only a handful of candidate genes possibly associated with hereditary or sporadic PCa. Cancer cells often rely for survival on common biochemical pathways such as enhanced anaerobic glycolysis and lipogenesis. The lipogenic enzyme fatty acid synthase seems to play a crucial part in PCa by conferring growth and survival advantages to cancer cells. We summarize the current understanding of the molecular events in PCa, and highlight the importance of altered lipid metabolism in the development and progression of prostate malignancy.
The pathogenesis of prostate cancer : from molecular to metabolic alterations / E. Benedettini, P. Nguyen, M. Loda. - In: DIAGNOSTIC HISTOPATHOLOGY. - ISSN 1756-2317. - 14:5(2008 May), pp. 195-201. [10.1016/j.mpdhp.2008.03.001]
The pathogenesis of prostate cancer : from molecular to metabolic alterations
E. BenedettiniPrimo
;
2008
Abstract
Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiological studies have identified only a handful of candidate genes possibly associated with hereditary or sporadic PCa. Cancer cells often rely for survival on common biochemical pathways such as enhanced anaerobic glycolysis and lipogenesis. The lipogenic enzyme fatty acid synthase seems to play a crucial part in PCa by conferring growth and survival advantages to cancer cells. We summarize the current understanding of the molecular events in PCa, and highlight the importance of altered lipid metabolism in the development and progression of prostate malignancy.File | Dimensione | Formato | |
---|---|---|---|
Benedittini.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
565.04 kB
Formato
Adobe PDF
|
565.04 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.