The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. The results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. The enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(II)-catalyzed asymmetric Henry reaction / A. Rossetti, S. Landoni, F. Meneghetti, C. Castellano, M. Mori, G. Colombo Dugoni, A. Sacchetti. - In: NEW JOURNAL OF CHEMISTRY. - ISSN 1144-0546. - 42:14(2018 Jul 21), pp. 12072-12081. [10.1039/c8nj01930d]

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(II)-catalyzed asymmetric Henry reaction

Fiorella Meneghetti;Carlo Castellano;Matteo Mori;
2018-07-21

Abstract

The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. The results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. The enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.
Settore CHIM/06 - Chimica Organica
Settore CHIM/07 - Fondamenti Chimici delle Tecnologie
Settore CHIM/08 - Chimica Farmaceutica
12-giu-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/579377
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