Retinoic acid syndrome is a potentially life-threatening complication of therapy for acute promyelocytic leukemia (APL) with all-transretinoic acid (ATRA). The case of a 55-year old male patient admitted to the hospital because of a bleeding diathesis is reported. APL was diagnosed and he underwent treatment with idarubicin and ATRA (GIMEMA protocol); 24 hrs after ATRA treatment he developed retinoic acid syndrome and was admitted to the Intensive Care Unit because of severe respiratory insufficiency (dyspnoea, tachypnea and severe hypoxemia (SpO2 75%). Pulmonary insufficiency was treated non-invasively with CPAP and the patient recovered from pulmonary distress one week later.
Titolo: | Sindrome da acido retinoico: grave insufficienza respiratoria trattata con ventilazione in maschera con CPAP |
Autori: | |
Parole Chiave: | Adult; Antineoplastic Agents; Humans; Leukemia, Promyelocytic, Acute; Male; Radiography; Respiratory Insufficiency; Tretinoin; Respiration, Artificial |
Settore Scientifico Disciplinare: | Settore MED/41 - Anestesiologia |
Data di pubblicazione: | 2000 |
Rivista: | |
Tipologia: | Article (author) |
Appare nelle tipologie: | 01 - Articolo su periodico |
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