To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for R0 and R2 (p = 0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p = 0.2), respectively. A better outcome was obtained for patients with a disease-free interval ≥36 months and ≥6 metastases and bilateral involvement were critical in achieving a R0 intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated.
Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland / L.D. Locati, M. Guzzo, P. Bossi, P.P.B. Massone, B. Conti, E. Fumagalli, C. Bareggi, G. Cantù, L. Licitra. - In: ORAL ONCOLOGY. - ISSN 1368-8375. - 41:9(2005 Oct), pp. 890-894. [10.1016/j.oraloncology.2005.04.014]
Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland
C. Bareggi;L. Licitra
2005
Abstract
To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for R0 and R2 (p = 0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p = 0.2), respectively. A better outcome was obtained for patients with a disease-free interval ≥36 months and ≥6 metastases and bilateral involvement were critical in achieving a R0 intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated.File | Dimensione | Formato | |
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