The ability of breakpoint and serum concentrations of teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin to select resistance was compared for isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus faecalis and Enterococcus faecium. Mutation frequencies were always <10(-10), except for two isolates grown in the presence of teicoplanin at the trough serum concentration. After multistep selection, linezolid selected for resistance in staphylococci and enterococci, and serial exposure to certain concentrations of linezolid was more likely to select for stable resistance in MRSA, MSSA and enterococci than was exposure to glycopeptides and quinupristin-dalfopristin.
A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp / L. Drago, L. Nicola, E. De Vecchi. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 14:6(2008 Jun), pp. 608-611. (Intervento presentato al 16. convegno ECCMID tenutosi a Nice nel 2006) [10.1111/j.1469-0691.2008.01993.x].
A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp
L. Drago
;E. De VecchiUltimo
2008
Abstract
The ability of breakpoint and serum concentrations of teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin to select resistance was compared for isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus faecalis and Enterococcus faecium. Mutation frequencies were always <10(-10), except for two isolates grown in the presence of teicoplanin at the trough serum concentration. After multistep selection, linezolid selected for resistance in staphylococci and enterococci, and serial exposure to certain concentrations of linezolid was more likely to select for stable resistance in MRSA, MSSA and enterococci than was exposure to glycopeptides and quinupristin-dalfopristin.File | Dimensione | Formato | |
---|---|---|---|
1-s2.0-S1198743X14619601-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
69.06 kB
Formato
Adobe PDF
|
69.06 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.