Reactive oxygen species (ROS) are widely considered to be a causal factor in aging and in a number of pathological conditions, such as atherosclerosis, carcinogenesis and infarction. Their role in bone metabolism is dual, considering their effects under physiological or pathological conditions. Under physiological conditions, the production of ROS by osteoclasts helps accelerate destruction of calcified tissue, thus assisting in bone remodeling. In pathological conditions, when a bone fractures, e.g., radical generation is remarkably high. However, though the increases in osteoclastic activity and ROS production are linked in many skeletal pathologies, it remains to be clarified whether increased ROS production overwhelms antioxidant defenses, leaving the individual open to hyperoxidant stress.

Oxidative stress, free radicals and bone remodeling / G. Banfi, E.L. Iorio, M.M. Corsi. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 46:11(2008), pp. 1550-1555.

Oxidative stress, free radicals and bone remodeling

G. Banfi
Primo
;
M.M. Corsi
Ultimo
2008

Abstract

Reactive oxygen species (ROS) are widely considered to be a causal factor in aging and in a number of pathological conditions, such as atherosclerosis, carcinogenesis and infarction. Their role in bone metabolism is dual, considering their effects under physiological or pathological conditions. Under physiological conditions, the production of ROS by osteoclasts helps accelerate destruction of calcified tissue, thus assisting in bone remodeling. In pathological conditions, when a bone fractures, e.g., radical generation is remarkably high. However, though the increases in osteoclastic activity and ROS production are linked in many skeletal pathologies, it remains to be clarified whether increased ROS production overwhelms antioxidant defenses, leaving the individual open to hyperoxidant stress.
Bone metabolism; Ethanol (EtOH); NADPH oxidase (Nox); Nitric oxide (NO); Osteoporosis; Oxidized low-density lipoprotein (OxLDL); Reactive oxygen species (ROS); Tartrate-resistant acid phosphatase (TRACP)
Settore MED/05 - Patologia Clinica
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
2008
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/57610
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