Objective - This study was performed to assess whether post-stress and rest functional parameters, as measured by gated-SPECT, provide additional predictive value for long-term prognosis, over clinical and perfusion data in patients (pts.) with low left ventricular ejection fraction (LVEF). Methods - 647 consecutive pts. underwent stress/rest gated-SPECT, and 497 were followed for a mean period of 516 ± 264 days. Segmental perfusion and motion/thickening (post-stress and rest) were analysed visually, while EF and LV volumes were calculated using an automatic algorithm (QGS). The post-stress and rest ratio were determined for both end-diastolic (EDV) and end-systolic volume (ESV), while the post-stress LVEF change was calculated subtracting rest-EF from stress-EF. Results - 84/497 pts. showed rest EF < 40%, and 15/ 84 (18%) experienced a cardiac event (3 cardiac deaths, 1 infarction, 3 hospitalized angina and 9 late revascularizations). The perfusion and functional parameters were not significantly more compromised in pts. with cardiac events compared with pts. without events. Post-stress ESV was the only index significantly higher in pts. with low EF and events compared with pts. with low EF without events (150 ± 72 ml vs. 123 ± 53 ml, P = 0.02). Univariate Cox analysis of clinical, perfusion and functional data showed that the best predictor of cardiac events was stress-ESV (score 6.5, P= 0.01), followed by rest-ESV, rest-EDV, stress-EDV and stress-LVEF. Multivariate analysis demonstrated that the addition of stress-ESV to stress-EF, yielded a significant increase in the global χ2 in the prediction of hard events (cardiac death/infarction) (score 4.634, P = 0.03). Conclusion - In patients with depressed LVEF, stress-ESV was the only independent predictor of long-term outcome.
|Titolo:||Enhanced prognostic stratification of CAD patients with low ejection fraction by stress-rest Tc99m tetrofosmin gated-spect|
|Autori interni:||BESTETTI, ALBERTO (Primo)|
|Parole Chiave:||99mTc-tetrofosmin; Dilated ventricle; Gated SPECT; Low ejection fraction|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||feb-2004|
|Appare nelle tipologie:||01 - Articolo su periodico|
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