The purpose of this study was to investigate the presence of risk factors for node metastases and to estimate survival in patients with cervical cancer, stages IB and IIA. In a retrospective study of 103 patients with cervical cancer stages IB and IIA, all treated with radical hysterectomy and adjuvant radiotherapy, we estimated survival curves according to different prognostic parameters. Mean follow-up time was 97 months. A significant difference between clinical pre-operative assessment and histological determination of real extent of the disease was evidenced. Pelvic lymph node metastases (P = 0.0005) significantly correlated with survival. This study shows that only lymph node involvement is an independent prognostic factor. Stage acts through nodal status in its impact on survival. A surgical-pathological staging in early stage cervical cancers is found to be more appropriate to correctly estimate patients' survival and prognosis.

Prognostic Factors in Patients with Locally Advanced Cervical Cancer Treated with Radical Hysterectomy and Adjuvant Radiotherapy / L. Frigerio, A. Mariani, L. Gandini, M. Origoni, L. Galli, E. Rabaiotti, G. Aletti, A. Ferrari. - In: INTERNATIONAL SURGERY. - ISSN 0020-8868. - 83:3(1998), pp. 265-270.

Prognostic Factors in Patients with Locally Advanced Cervical Cancer Treated with Radical Hysterectomy and Adjuvant Radiotherapy

M. Origoni;G. Aletti;
1998

Abstract

The purpose of this study was to investigate the presence of risk factors for node metastases and to estimate survival in patients with cervical cancer, stages IB and IIA. In a retrospective study of 103 patients with cervical cancer stages IB and IIA, all treated with radical hysterectomy and adjuvant radiotherapy, we estimated survival curves according to different prognostic parameters. Mean follow-up time was 97 months. A significant difference between clinical pre-operative assessment and histological determination of real extent of the disease was evidenced. Pelvic lymph node metastases (P = 0.0005) significantly correlated with survival. This study shows that only lymph node involvement is an independent prognostic factor. Stage acts through nodal status in its impact on survival. A surgical-pathological staging in early stage cervical cancers is found to be more appropriate to correctly estimate patients' survival and prognosis.
cervical cancer; lymph node metastases; radical hysterectomy; adjuvant radiotherapy; survival
Settore MED/40 - Ginecologia e Ostetricia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/575764
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