Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms. They are varied in their biological and clinical behavior: most have endocrine function and they secrete peptides that cause distinct clinical syndromes, including carcinoid syndrome; many are clinically silent until late presentation. Investigation and management should be individualized for each patient, taking into consideration the natural history of the tumour and general health of the patient. Management strategies include surgery and other cytoreductive techniques for cure and palliation and medical treatment including chemotherapy and biotherapy (somatostatin analogues and alpha-inteferon) to control symptoms and tumor growth. New biological agents and peptide receptor radionuclide therapy are under investigation.
I Tumori Neuroendocrini del tratto gastro-entero-pancreatico / S. Massironi, D. Conte, M. Peracchi. - In: ARGOMENTI DI GASTROENTEROLOGIA CLINICA. - ISSN 1120-8651. - 21:2(2008 Sep), pp. 41-48.
I Tumori Neuroendocrini del tratto gastro-entero-pancreatico
S. MassironiPrimo
;D. ConteSecondo
;M. PeracchiUltimo
2008
Abstract
Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms. They are varied in their biological and clinical behavior: most have endocrine function and they secrete peptides that cause distinct clinical syndromes, including carcinoid syndrome; many are clinically silent until late presentation. Investigation and management should be individualized for each patient, taking into consideration the natural history of the tumour and general health of the patient. Management strategies include surgery and other cytoreductive techniques for cure and palliation and medical treatment including chemotherapy and biotherapy (somatostatin analogues and alpha-inteferon) to control symptoms and tumor growth. New biological agents and peptide receptor radionuclide therapy are under investigation.Pubblicazioni consigliate
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