Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome) / L. Guazzarotti, D.L. Trabattoni, E. Castelletti, B. Boldrighini, L. Piacentini, P. Duca, S. Beretta, M. Pacei, C. Caprio, A. Viganò, B. di Natale, G.V. Zuccotti, M.S. Clerici. - In: AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES. - ISSN 1944-7558. - 114:2(2009 Mar), pp. 100-109.

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

D.L. Trabattoni;E. Castelletti;B. Boldrighini;L. Piacentini;P. Duca;S. Beretta;M. Pacei;B. di Natale;G.V. Zuccotti;M.S. Clerici
2009-03

Abstract

Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.
Settore MED/01 - Statistica Medica
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/04 - Patologia Generale
Settore MED/25 - Psichiatria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/57427
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