Lung transplantation is a clinica reality but survival rates are still improving. In this scenario primary graft dysfunction (PGD) is the major cause of mortality in the first 30 days after lung tranplantation and its pathogenesis remains poorly understood. MicroRNAs are ubiquitous regulators of human biology and emerging evidence indicates microRNA expression modulates disease processes. We aimed to identify microRNAs biomarker of PGD and their contribution in the PGD pathogenesis.
MiRNA’s profiling and primary graft dysfunction: novel non-invasive biomarkers / A. Palleschi, V. Vaira, G. Gaudioso, M. Formica, V. Musso, R. Carrinola, L. Morlacchi, P. Tarsia, A. Terrasi, L. Rosso, S. Ferrero Bogetto. - In: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. - ISSN 1053-2498. - 37:4 suppl.(2018 Apr), pp. S458-S459. (Intervento presentato al 28. convegno Annual Meeting ISHLT (International Society Heart Lung Transplantation) tenutosi a Nizza nel 2018).
MiRNA’s profiling and primary graft dysfunction: novel non-invasive biomarkers
A. Palleschi;V. Vaira;L. Rosso;S. Ferrero Bogetto
2018
Abstract
Lung transplantation is a clinica reality but survival rates are still improving. In this scenario primary graft dysfunction (PGD) is the major cause of mortality in the first 30 days after lung tranplantation and its pathogenesis remains poorly understood. MicroRNAs are ubiquitous regulators of human biology and emerging evidence indicates microRNA expression modulates disease processes. We aimed to identify microRNAs biomarker of PGD and their contribution in the PGD pathogenesis.
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