Ireg1 is highly expressed in the plasma membrane of Ireg1-injected oocytes. Iron uptake in DCT1 plus Ireg-1 injected oocytes did not significantly differ from DCT1 alone injected oocytes. Iron efflux needed Ceruloplasmine and aporansferrin. We demostrated that Ireg1 can mediate iron efflux across membranes by a mechanism which requires a ferroxidase activity and tf as an iron acceptor.
Expression of a duodenal iron-regulated transporter, Ireg1, in Xenopus laevis oocytes / P. Marciani, A. Rolfs, A.T. Mckie, M.A. Hediger. ((Intervento presentato al 51. convegno Riunione autunnale Società Italiana di Fisiologia tenutosi a Catania nel 2000.
Expression of a duodenal iron-regulated transporter, Ireg1, in Xenopus laevis oocytes
P. Marciani
Primo
Investigation
;
2000
Abstract
Ireg1 is highly expressed in the plasma membrane of Ireg1-injected oocytes. Iron uptake in DCT1 plus Ireg-1 injected oocytes did not significantly differ from DCT1 alone injected oocytes. Iron efflux needed Ceruloplasmine and aporansferrin. We demostrated that Ireg1 can mediate iron efflux across membranes by a mechanism which requires a ferroxidase activity and tf as an iron acceptor.
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