International scientific committees, regional scientific committees such as those of the European Union, and national regulatory agencies generally use the uncertainly factor approach for establishing acceptable or tolerable intakes of substances that exhibit thresholds of toxicity. No observed adverse effect levels (NOAELs) are identified in the critical studies to which appropriate uncertainly factors are applied to allocate acceptable daily intake (ADI). This paper discusses the different steps of the risk assessment process considered for decades worldwide a pragmatic approach to allocate safe doses, yet in need of improvements during the extrapolation phase which could increase the confidence level of the work performed by risk assessors
Is the acceptable daily intake as presently used an axiom or a dogma? / C.L. Galli, M. Marinovich, M. Lotti. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 180:2(2008 Jun 08), pp. 93-99. [10.1016/j.toxlet.2008.06.003]
Is the acceptable daily intake as presently used an axiom or a dogma?
C.L. GalliPrimo
;M. MarinovichSecondo
;
2008
Abstract
International scientific committees, regional scientific committees such as those of the European Union, and national regulatory agencies generally use the uncertainly factor approach for establishing acceptable or tolerable intakes of substances that exhibit thresholds of toxicity. No observed adverse effect levels (NOAELs) are identified in the critical studies to which appropriate uncertainly factors are applied to allocate acceptable daily intake (ADI). This paper discusses the different steps of the risk assessment process considered for decades worldwide a pragmatic approach to allocate safe doses, yet in need of improvements during the extrapolation phase which could increase the confidence level of the work performed by risk assessorsPubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.