A cDNA clone up-regulated in hydraulic lung edema in rabbit showed high similarity with human RDH10 mRNA, which encodes a protein involved in retinoic acid metabolism. We defined the organization of the human gene, which includes a unique transcriptional start site, a coding region with six translated exons and a 3′ untranslated region containing at least two used polyadenylation sites. The two poly(A) signals are responsible for the production of the 3 and 4 kb RDH10 mRNA isoforms detected in several human tissues and cell lines.
Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene / P. Picozzi, A. Marozzi, D. Fornasari, R. Benfante, D. Barisani, R. Meneveri, E. Ginelli. - In: FEBS LETTERS. - ISSN 0014-5793. - 554:1-2(2003 Nov 06), pp. 59-66. [10.1016/S0014-5793(03)01089-5]
Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene
P. PicozziPrimo
;A. MarozziSecondo
;D. Fornasari;R. Benfante;E. GinelliUltimo
2003
Abstract
A cDNA clone up-regulated in hydraulic lung edema in rabbit showed high similarity with human RDH10 mRNA, which encodes a protein involved in retinoic acid metabolism. We defined the organization of the human gene, which includes a unique transcriptional start site, a coding region with six translated exons and a 3′ untranslated region containing at least two used polyadenylation sites. The two poly(A) signals are responsible for the production of the 3 and 4 kb RDH10 mRNA isoforms detected in several human tissues and cell lines.
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