The use of pesticides has become unavoidable in agriculture as it ensures the massive production of food crops and their global trade, as well as solves public health problems by eradicating vectors of human diseases such as malaria. Besides risk assessment done in the pre-marketing phase, field studies allow for the re-evaluation of exposure and risk in real-life working conditions, opening new possibilities for risk assessment and modeling. In agriculture, special attention must be given to the skin as the main route of exposure, but the fixed fractional approach to dermal absorption might not represent the perfect solution to absorbed dose assessment. Here we present a practical method for integrating the information on the duration of exposure into the absorbed dose assessment, using a group of mancozeb applicators as a case study. Assumption of an 8-hour exposure resulted in a gross overestimation of absorbed dose from hands’ exposure. Absorbed dose from body exposure was overestimated in those workers working less than 8 hours, but somewhat underestimated in those working more than 8 hours, which is common in agriculture. In total, an 80% reduction of the absorbed dose estimate resulted from the introduction of the duration of exposure as a factor. This reduction did not influence risk assessment significantly for substances with low toxicity such as mancozeb, but implications for modeling might be much more important.
Duration of Skin Exposure: a Neglected Variable in Absorbed Dose Assessment / S. Mandic-Rajcevic, F.M. Rubino, C. Colosio - In: Book of Abstracts / [a cura di] V. Matovic. - Beograd : Serbian Society of Toxicology, 2018 Apr 20. - ISBN 9788691786717. - pp. 17-18 (( Intervento presentato al 10. convegno Congress of Toxicology in Developing Countries tenutosi a Belgrade nel 2018.
|Titolo:||Duration of Skin Exposure: a Neglected Variable in Absorbed Dose Assessment|
MANDIC-RAJCEVIC, STEFAN (Primo) (Corresponding)
RUBINO, FEDERICO MARIA (Secondo)
COLOSIO, CLAUDIO (Ultimo)
|Parole Chiave:||methodology; patch; biological monitoring; absorbed dose assessment; modeling|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||20-apr-2018|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|