Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.
From jamming to collective cell migration through a boundary induced transition / O. Chepizhko, M.C. Lionetti, C. Malinverno, C. Giampietro, G. Scita, S. Zapperi, C.A.M. La Porta. - In: SOFT MATTER. - ISSN 1744-683X. - 14:19(2018 May 01), pp. 3774-3782.
|Titolo:||From jamming to collective cell migration through a boundary induced transition|
ZAPPERI, STEFANO (Corresponding)
LA PORTA, CATERINA (Corresponding)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore FIS/03 - Fisica della Materia
|Data di pubblicazione:||1-mag-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/c8sm00128f|
|Appare nelle tipologie:||01 - Articolo su periodico|