Background Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear. Methods Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain. Results The prevalence of bvFTD varied between 0.2% and 0.5% at age 70 to 79 years, between 2.5% and 3.6% at age 80 to 89 years, and between 1.7% and 2.2% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3% had frontal and/or temporal lobar atrophy on CT, compared with 12.6% of those without bvFTD (P <.001). Conclusions The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.
Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly / T.B. Gislason, S. Östling, A. Börjesson-Hanson, M. Sjögren, M. Simoni, L. Pantoni, I. Skoog. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - 11:4(2015 Apr), pp. 425-433.
|Titolo:||Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly|
|Parole Chiave:||Aged; Frontotemporal dementia; Prevalence; Tomography; X-ray computed; Age Distribution; Aged; Aged, 80 and over; Brain; Chi-Square Distribution; Cluster Analysis; Community Health Planning; Female; Frontotemporal Dementia; Humans; Male; Prevalence; Psychiatric Status Rating Scales; Retrospective Studies; Sex Distribution; Sweden; Tomography, X-Ray Computed; Epidemiology; Health Policy; Developmental Neuroscience; Neurology (clinical); Geriatrics and Gerontology; Cellular and Molecular Neuroscience; Psychiatry and Mental Health|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||apr-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jalz.2014.03.002|
|Appare nelle tipologie:||01 - Articolo su periodico|
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