Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.
Visuospatial Functioning in Cerebral Amyloid Angiopathy : a Pilot Study / R. Valenti, A. Charidimou, L. Xiong, G. Boulouis, P. Fotiadis, A. Ayres, G. Riley, H.J. Kuijf, Y.D. Reijmer, L. Pantoni, M.E. Gurol, S. Davidsdottir, S.M. Greenberg, A. Viswanathan. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 56:4(2017), pp. 1223-1227. [10.3233/JAD-160927]
Visuospatial Functioning in Cerebral Amyloid Angiopathy : a Pilot Study
L. Pantoni;
2017
Abstract
Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.File | Dimensione | Formato | |
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