Aims: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. Materials & methods: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. Results: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). Conclusion: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.
Lgr5 expression, cancer stem cells and pancreatic cancer: Results from biological and computational analyses / K. Andrikou, M. Santoni, F. Piva, A. Bittoni, A. Lanese, C. Pellei, A. Conti, C. Loretelli, A. Mandolesi, M. Giulietti, M. Scarpelli, G. Principato, M. Falconi, S. Cascinu. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 11:7(2015 Apr 01), pp. 1037-1045. [10.2217/fon.15.27]
Lgr5 expression, cancer stem cells and pancreatic cancer: Results from biological and computational analyses
C. Loretelli;
2015
Abstract
Aims: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. Materials & methods: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. Results: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). Conclusion: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.
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