We explored the influence of polymorphisms in genes encoding the chemokine stromal cellderived factor-1 (SDF-1)/CXCL12 in a cohort of Tunisian patients with malignant hematologic diseases multiple myeloma [MM], non-Hodgkin's lymphoma [NHL], Hodgkin's disease, and acute myeloid leukemia [AML], who underwent stem cell mobilization for autologous transplantation versus a group of healthy donors for allogeneic transplantation. Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLp) analysis was used for rapid identification of genotypes. Significant associations for SDF1-3â²A polymorphism were observed exclusively in patients with MM and NHL. While there was a lack of all association of SDF-1 polymorphism with AML patients. However, considering that the ability of mobilization varies among subjects, we have observed that the SDF1-3â²A allele was associated with good mobilization capacity. Interestingly, the association was mainly observed among healthy allogeneic transplant donors where the analysis was not biased by background disease or chemotherapy (P = .010; odds ratio = 2.603; confidence interval [95%] = 1.2395.466).
Association of Stromal Cell-Derived Factor-1-3 ' A Polymorphism to Higher Mobilization of Hematopoietic Stem Cells CD34+in Tunisian Population / M. Ben Nasr, Z. Reguaya, L. Berraies, M. Maamar, S. Ladeb, T. Ben Othmen, F. Mellouli, M. Bjaoui, J. Domenech, F. Jenhani. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 43:2(2011), pp. 635-638. ((Intervento presentato al 12. convegno Congress of the Middle-East-Society-for-Organ-Transplantation (MESOT) tenutosi a Tunis nel 2010.
|Titolo:||Association of Stromal Cell-Derived Factor-1-3 ' A Polymorphism to Higher Mobilization of Hematopoietic Stem Cells CD34+in Tunisian Population|
BEN NASR, MOUFIDA (Primo)
|Parole Chiave:||Lymphoma patients; peripheral-blood; transplantation; translation; chemokine; allele; hard|
|Settore Scientifico Disciplinare:||Settore MED/50 - Scienze Tecniche Mediche Applicate|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.transproceed.2011.01.016|
|Appare nelle tipologie:||01 - Articolo su periodico|