High density multielectrode array recordings with CMOS-MEAs allow to monitor cell culture activity with unprecedent details respect to previous recording techniques. This is clarifying how network activity develops and is motivating the development of novel data analysis tools. Here, in order to advance in the exploitation of the richness of these large-scale array recordings, we introduce a principal component analysis approach that aims at improving on existing methodologies to describe neural activity events within large networks.
Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques / T. Nieus, S. Di Marco, A. Maccione, H. Amin, L. Berdondini (PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE[s.l] : IEEE, 2015. - ISBN 9781424492718. - pp. 3759-3762 (( Intervento presentato al 37. convegno EMBC tenutosi a Milano nel 2015.
Titolo: | Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques |
Autori: | |
Parole Chiave: | Action Potentials; Adrenergic alpha-Agonists; Animals; Cell Culture Techniques; Cells, Cultured; Electric Stimulation; Electrodes; Hippocampus; Nerve Net; Neurons; Norepinephrine; Principal Component Analysis; Signal Processing; Biomedical Engineering; 1707; Health Informatics |
Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) Settore ING-INF/06 - Bioingegneria Elettronica e Informatica |
Data di pubblicazione: | 2015 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1109/EMBC.2015.7319211 |
Tipologia: | Book Part (author) |
Appare nelle tipologie: | 03 - Contributo in volume |
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