A combinatorial approach to 2,4,6-trisubstituted triazines with potent antimalarial activity : combining conventional synthesis and microwave-assistance

(Chemical Equation Presented) Managing malaria. Malaria is responsible for two million deaths per year particularly in developing countries, therefore there is great need for the development of cost effective treatment. The synthesis of a library of trisubstituted triazines with potent antimalarial in vitro activity is reported. Among them, five products may be developed as potential leads in the search for new drugs against plasmodial chloroquine-resistant strains.